Organometallic Compounds

Organometallic Compounds
Accession Number

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

DrugDrug Description
CarboplatinA alkylating agent used to treat advanced ovarian cancer.
Iron sucroseAn compound used as a source of iron in patients with iron deficiency anemia associated with chronic kidney disease (CKD).
Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
Ferrous sulfate anhydrousAn iron supplement used to prevent or treat iron deficiency anemia.
Tetraferric tricitrate decahydrateA phosphate binder used to control serum phosphorus levels or as an iron supplement.
Ferric oxyhydroxideAn ingredient used to treat hyperphosphatemia in patients with renal failure or patients on dialysis.
SucralfateA gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence.
Ferric maltolA complexed iron supplement used to treat iron deficiency in adults.
Technetium Tc-99m arcitumomabFor imaging colorectal tumors
ChlormerodrinPreviously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
AuranofinAn antirheumatic used to treat active, progressive, or destructive forms of inflammatory arthritis.
p-Hydroxymercuribenzoic acidNot Available
PicoplatinFor the treatment of patients with solid tumors.
AP5346For the treatment of various forms of cancer.
SatraplatinInvestigated for use/treatment in lung cancer, prostate cancer, and solid tumors.
AP5280Investigated for use/treatment in solid tumors.
Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
TributyltinNot Available
Bamet-UD2Bamet-UD2 is a novel bile acid-platinum derivative.
cis-Diamminechlorocholylglycinateplatinum(II)Not Annotated
AurothioglucoseA gold compound used in the treatment of rheumatoid arthritis.
Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is...
Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary...
Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
Technetium Tc-99m nofetumomab merpentanTc-99m nm is one of the technetium-labeled antibodies and it is indicated for the detection of small-cell lung cancer. The small cell lung cancer is a syndrome characterized by the...
MersalylElevated blood pressure, edema [L1577, L1585].
Technetium Tc-99m etidronateNot Annotated
Technetium Tc-99m succimerA radioactive diagnostic agent used as an aid in the scintigraphic evaluation of renal parenchymal disorders.
ThimerosalUsed as preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines [L1671, L1672, L1673].
LobaplatinLobaplatin has been used in trials studying the treatment of Breast Cancer, Hepatocellular Carcinoma, and Lobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma.
NedaplatinUsed in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers .
MerbrominA topical antiseptic indicated in the disinfection of lacerations.
AurotioprolNot Annotated
Thiosalicylic acidNot Annotated
Demplatin pegraglumerDemplatin pegraglumer is under investigation in clinical trial NCT02043288 (Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer).
Phenylmercuric acetatePhenylmercuric acetate is an organomercurial compound used as a fungicide and slimicide.
AroplatinNot Annotated
99mTc-HYNIC (Tyr3)-octreotideNot Annotated
Drugs & Drug Targets
CarboplatinHigh affinity copper uptake protein 1transporter
CarboplatinProbable low affinity copper uptake protein 2transporter
CarboplatinXanthine dehydrogenase/oxidaseenzyme
CarboplatinGlutathione S-transferase theta-1enzyme
CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
CarboplatinGlutathione S-transferase Penzyme
CarboplatinGlutathione S-transferase Mu 1enzyme
CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CarboplatinCopper-transporting ATPase 1transporter
CarboplatinCopper-transporting ATPase 2transporter
CarboplatinATP-binding cassette sub-family G member 2transporter
CarboplatinCanalicular multispecific organic anion transporter 1transporter
Ferrous sulfate anhydrousNatural resistance-associated macrophage protein 2transporter
Ferrous sulfate anhydrousCeruloplasminenzyme
Ferrous sulfate anhydrousHemoglobin subunit alphatarget
Ferrous sulfate anhydrousTransferrin receptortarget
Ferrous sulfate anhydrousSolute carrier family 40 member 1transporter
Ferrous sulfate anhydrousHepcidinenzyme
Ferrous sulfate anhydrousSerotransferrinenzyme
Ferrous sulfate anhydrousHephaestinenzyme
Ferrous sulfate anhydrousCytochrome b reductase 1enzyme
Tetraferric tricitrate decahydrateSerotransferrincarrier
Tetraferric tricitrate decahydrateIron(3+)-hydroxamate-binding protein FhuDtarget
Tetraferric tricitrate decahydrateIntegrin beta-3carrier
Tetraferric tricitrate decahydrateCalreticulincarrier
Tetraferric tricitrate decahydrateTransferrin receptor protein 1target
Tetraferric tricitrate decahydrateNatural resistance-associated macrophage protein 2transporter
Tetraferric tricitrate decahydrateSolute carrier family 40 member 1transporter
Tetraferric tricitrate decahydrateCytochrome b reductase 1enzyme
SucralfatePepsin A-5target
SucralfatePro-epidermal growth factortarget
SucralfateFibroblast growth factor 2target
Ferric maltolUDP-glucuronosyltransferase 1-6enzyme
Ferric maltolIntegrin beta-3target
Ferric maltolNatural resistance-associated macrophage protein 2target
Ferric maltolNatural resistance-associated macrophage protein 2transporter
Ferric maltolIntegrin beta-3transporter
Technetium Tc-99m arcitumomabCarcinoembryonic antigen-related cell adhesion molecule 1target
ChlormerodrinSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
ChlormerodrinSolute carrier family 12 member 1target
AuranofinInhibitor of nuclear factor kappa-B kinase subunit betatarget
AuranofinSerum albumincarrier
AuranofinPeroxiredoxin-5, mitochondrialtarget
p-Hydroxymercuribenzoic acidCarbonic anhydrase 2target
Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
TributyltinNuclear receptor coactivator 2target
TributyltinRetinoic acid receptor RXR-alphatarget
Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
cis-Diamminechlorocholylglycinateplatinum(II)Solute carrier organic anion transporter family member 1B1transporter
AurothioglucoseAdenylate cyclase type 1target
AurothioglucoseAdenylate cyclase type 2target
AurothioglucoseAdenylate cyclase type 5target
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
Technetium Tc-99m oxidronateSerum albumincarrier
Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
Technetium Tc-99m sestamibiP-glycoprotein 1transporter
Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
Technetium Tc-99m nofetumomab merpentanEpithelial cell adhesion moleculetarget
Technetium Tc-99m nofetumomab merpentanB-lymphocyte antigen CD20target
MersalylAlkaline phosphatase, tissue-nonspecific isozymetarget
MersalylMonocarboxylate transporter 1target
MersalylInter-alpha-trypsin inhibitor heavy chain H1enzyme
MersalylPhosphoenolpyruvate carboxykinase, cytosolic [GTP]enzyme
Technetium Tc-99m succimerSodium-dependent phosphate transporter 1transporter
Technetium Tc-99m succimerSodium-dependent phosphate transporter 2transporter
ThimerosalSerum albumincarrier
ThimerosalInositol 1,4,5-trisphosphate receptor type 1transporter
ThimerosalMethionine synthasetarget
ThimerosalCystine/glutamate transportertarget
ThimerosalSodium/potassium-transporting ATPase subunit gammatarget
ThimerosalGlutathione reductase, mitochondrialenzyme
ThimerosalGlutathione peroxidase 1enzyme
ThimerosalSuperoxide dismutase [Mn], mitochondrialenzyme