DNA polymerase beta

BE0000113ProteinHumansPOLB

Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). It is acted on by 13 drugs in DrugBank.

Gene name
POLB
UniProtKB entry
P06746Swiss-Prot
Cellular location
Nucleus
Residues / weight
335 residues · 38,177 Da
Also known as
2.7.7.7 · 5'-deoxyribose-phosphate lyase · 5'-dRP lyase · AP lyase

Resolves to

Protein
UniProtP06746UniProt nameDPOLB_HUMAN
Gene
HGNCHGNC:9174NCBI Gene5423GenBank292397GeneCardsPOLB
Pharmacology
IUPHAR/GtoPdb3231KEGGhsa:5423
Structure
PDB1BPXPDB1BPYPDB1BPZ
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
18GO termsFunction, process and component, as structured annotations
Sign in
4Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
33+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA polymerase beta, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In