Human papillomavirus type 16 L1 capsid protein antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Human papillomavirus type 16 L1 capsid protein antigen
Accession Number
DB10301
Description

Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant Saccharomyces cerevisiae and self-assembled into VLPs.

Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Other vaccines
Synonyms
  • L1 protein, Human papillomavirus type 16 Vaccine
  • Recombinant human papillomavirus type 16 L1 protein

Pharmacology

Indication
Not Available
Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
CervarixHuman papillomavirus type 16 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg)SuspensionIntramuscularGlaxosmithkline Inc2010-02-10Not applicableCanada flag
GardasilHuman papillomavirus type 16 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (20 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2006-06-08Not applicableUS flag
GardasilHuman papillomavirus type 16 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (20 ug/0.5mL)Injection, suspensionIntramuscularRemedy Repack2014-02-132015-02-11US flag
GardasilHuman papillomavirus type 16 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (20 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2006-06-08Not applicableUS flag
GardasilHuman papillomavirus type 16 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (20 mcg)SuspensionIntramuscularMerck Ltd.2006-08-162019-08-22Canada flag
GardasilHuman papillomavirus type 16 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (20 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2006-06-08Not applicableUS flag
Gardasil 9Human papillomavirus type 16 L1 capsid protein antigen (60 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 45 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 ug/0.5mL)Injection, suspensionIntramuscularA-S Medication Solutions2014-12-10Not applicableUS flag
Gardasil 9Human papillomavirus type 16 L1 capsid protein antigen (60 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 45 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2014-12-10Not applicableUS flag
Gardasil 9Human papillomavirus type 16 L1 capsid protein antigen (60 ug/0.5mL) + Human papillomavirus type 11 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 18 L1 capsid protein antigen (40 ug/0.5mL) + Human papillomavirus type 31 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 33 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 45 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 52 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 58 L1 capsid protein antigen (20 ug/0.5mL) + Human papillomavirus type 6 L1 capsid protein antigen (30 ug/0.5mL)Injection, suspensionIntramuscularMerck Sharp & Dohme Corp.2014-12-10Not applicableUS flag
Gardasil 9Human papillomavirus type 16 L1 capsid protein antigen (60 mcg) + Human papillomavirus type 11 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 18 L1 capsid protein antigen (40 mcg) + Human papillomavirus type 31 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 33 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 45 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 52 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 58 L1 capsid protein antigen (20 mcg) + Human papillomavirus type 6 L1 capsid protein antigen (30 mcg)SuspensionIntramuscularMerck Ltd.2015-03-18Not applicableCanada flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
6LTE2DNX63
CAS number
Not Available

References

General References
Not Available
PubChem Substance
347910487
RxNav
798264

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4Active Not RecruitingPreventionAnti-HPV Antibody Patterns / Cervical Cancers / Cervical HPV Infection / Sexually Transmitted Infections (STIs)1
4Active Not RecruitingPreventionCervical Cancers / Cervical Precancerous Lesions1
4Active Not RecruitingPreventionPapillomavirus Infections1
4CompletedHealth Services ResearchCervical Intraepithelial Neoplasia (CIN) / HPV-Related Cervical Carcinoma1
4CompletedOtherHealthy Volunteers1
4CompletedPreventionAdenocarcinoma in Situ / Cervical Cancers / Cervical Intraepithelial Neoplasia (CIN)1
4CompletedPreventionAIN / Human Immunodeficiency Virus (HIV) Infections1
4CompletedPreventionCervical Cancers3
4CompletedPreventionCervical Intraepithelial Neoplasia (CIN)1
4CompletedPreventionHuman Immunodeficiency Virus (HIV) Infections / Human Papillomavirus (HPV)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionIntramuscular20 mcg
Injection, suspensionIntramuscular
Injection, suspensionIntramuscular; Parenteral20 mcg
SuspensionIntramuscular
SuspensionIntramuscular20 µg
Injection, suspensionIntramuscular; Parenteral40 µg
Injection, solutionIntramuscular40 mcg
SuspensionIntramuscular40 mcg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on December 01, 2015 13:03 / Updated on June 12, 2020 10:53

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