Human papillomavirus type 16 L1 capsid protein antigen

Identification

Brand Names

Cervarix, Gardasil, Gardasil 9

Generic Name

Human papillomavirus type 16 L1 capsid protein antigen

DrugBank Accession Number

DB10301

Background

Human papillomavirus type 16 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) types 6, 11, 16 and 18. The vaccine is prepared from the purified virus-like particles (VLPs) of the major capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant Saccharomyces cerevisiae and self-assembled into VLPs.

Type

Biotech

Groups

Approved, Investigational

Biologic Classification

Vaccines
Other vaccines

Synonyms

• L1 protein, Human papillomavirus type 16 Vaccine
• Recombinant human papillomavirus type 16 L1 protein

Pharmacology

Indication

Not Available

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Associated Conditions

• Human Papillomavirus (HPV) Infections
• Infection caused by human papillomavirus type 16

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

Products

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
CERVARIX	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection	Intramuscular	บริษัท แกล็กโซสมิทไคล์น (ประเทศไทย) จำกัด	2011-08-18	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg / 0.5 mL) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg / 0.5 mL)	Suspension	Intramuscular	Glaxosmithkline Inc	2010-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable
Cervarix	Human papillomavirus type 16 L1 capsid protein antigen (20 mcg/0.5ml) + Human papillomavirus type 18 L1 capsid protein antigen (20 mcg/0.5ml)	Injection, suspension	Intramuscular	Glaxo Smith Kline Biologicals S.A.	2021-02-10	Not applicable

Categories

Drug Categories

• Actively Acquired Immunity
• Amino Acids, Peptides, and Proteins
• Cancer immunotherapy
• Human papillomavirus 16
• Immunotherapy
• Inactivated Human Papillomavirus Vaccine
• Neoplasm Proteins
• Nucleocapsid Proteins
• Oncogene Proteins
• Proteins
• Viral Proteins
• Viral Structural Proteins

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

6LTE2DNX63

CAS number

Not Available

References

General References

Not Available

External Links

PubChem Substance

347910487

RxNav

798264

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Prevention	Allogeneic Hematopoietic Stem Cell Transplantation Recipient / Hematopoietic and Lymphoid System Neoplasm	1
4	Active Not Recruiting	Prevention	Cervical Cancer / Precancerous Cervical Lesions	1
4	Active Not Recruiting	Prevention	Cervical Carcinoma / Human Papillomavirus (HPV) Infections	1
4	Active Not Recruiting	Prevention	Coronavirus Disease 2019 (COVID‑19) / Human Papillomavirus (HPV) Infections	1
4	Active Not Recruiting	Prevention	HPV Vaccinations / Human Papilloma Virus (HPV)	1
4	Active Not Recruiting	Prevention	Human Immunodeficiency Virus (HIV) Infections / Human Papilloma Virus (HPV) / Human Papillomavirus (HPV) Vaccine	1
4	Active Not Recruiting	Prevention	Human Papilloma Virus (HPV)	1
4	Active Not Recruiting	Prevention	Human Papilloma Virus (HPV) / Vaccine Preventable Diseases	1
4	Active Not Recruiting	Prevention	Papilloma Viral Infection	1
4	Completed	Health Services Research	Cervical Intraepithelial Neoplasia (CIN) / HPV-Related Cervical Carcinoma	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection	Intramuscular
Injection, suspension	Intramuscular	20 mcg/0.5ml
Injection, suspension	Intramuscular
Suspension	Intramuscular
Suspension	Parenteral
Injection, suspension	Intramuscular; Parenteral
Injection, solution	Intramuscular
Injection, suspension	Intramuscular	40 mcg
Solution	Intramuscular
Injection
Injection, suspension

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

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Drug created at December 01, 2015 20:03 / Updated at February 13, 2021 10:52