Oxilofrine is an amphetamine used to treat a cough associated with inflamed mucosa. It is currently marketed in Canada by Valeant under the tradename Cophylac.
- Mechanism
- Curator reviewed
Oxilofrine is likely helps to treat cough by stimulating α1 adrenergic receptors resulting in vasoconstriction. This would serve to reduce secretion of mucus into the airway and lessen the stimulus to cough.
- Primary indication
- Used in combination with DB11609 as an antitussive.Curator reviewed
- Formula / weight
- C10H15NO2 · 181.235 g/mol (avg)
- First approval
- Canada, 2019
- Also known as
- 4-HMP · 4-hydroxyephedrine · Methyl synephrin · Methyl synephrine · Methylsympatol
- Code names
- J5.704E
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
OXFGTKPPFSCSMA-XVKPBYJWSA-NSMILES[H][C@@](C)(NC)[C@]([H])(O)C1=CC=C(O)C=C1Targets
What you can answer from here — as of August 30, 2026
Which drugs share a target with Oxilofrine, and which of those have an active Phase 3 trial?
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