Non-Alcoholic Steatohepatitis (NASH)

Also known as: Metabolic Dysfunction-associated Steatohepatitis (MASH) / MASH / Nash / NASH/MASH / NASH (Non-Alcoholic Steatohepatitis) / Nonalcoholic steatohepatitis (NASH) / NASH - Nonalcoholic steatohepatitis / Nonalcoholic steatohepatitis (disorder) / Nonalcoholic Steatohepatitis / Non-alcoholic steatohepatitis

Drug	Drug Name	Drug Description
DB12914	Resmetirom	A thyroid hormone receptor-beta agonist used to treat noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults.

Drug	Drug Name	Target	Type
DB12914	Resmetirom	Cytochrome P450 2C8	enzyme
DB12914	Resmetirom	UDP-glucuronosyltransferase 1-4	enzyme
DB12914	Resmetirom	UDP-glucuronosyltransferase 1-9	enzyme
DB12914	Resmetirom	Solute carrier organic anion transporter family member 1B1	transporter
DB12914	Resmetirom	Solute carrier organic anion transporter family member 1B3	transporter
DB12914	Resmetirom	ATP-binding cassette sub-family G member 2	transporter
DB12914	Resmetirom	Solute carrier family 22 member 8	transporter
DB12914	Resmetirom	Bile salt export pump	transporter
DB12914	Resmetirom	Thyroid hormone receptor beta	target

Drug	Drug Name	Phase	Status	Count
DB18031	Linafexor	Not Available	Not Yet Recruiting	1
DB15386	ALT-801	1	Completed	2
DB11860	Aramchol	1	Completed	1
DB01076	Atorvastatin	1	Completed	1
DB15125	Belapectin	1	Completed	1
DB18293	CM-101	1	Completed	1
DB00201	Caffeine	1	Completed	1
DB15168	Cilofexor	1	Completed	2
DB18956	Clesacostat	1	Withdrawn	1
DB18203	Cudetaxestat	1	Completed	1
DB00390	Digoxin	1	Completed	1
DB00977	Ethinylestradiol	1	Completed	2
DB01039	Fenofibrate	1	Completed	1
DB16166	Firsocostat	1	Completed	1
DB00196	Fluconazole	1	Completed	1
DB00176	Fluvoxamine	1	Completed	1
DB11242	Gelatin	1	Completed	1
DB00367	Levonorgestrel	1	Completed	1
DB00331	Metformin	1	Completed	1
DB00683	Midazolam	1	Completed	1
DB16234	Miricorilant	1	Completed	1
DB16234	Miricorilant	1	Recruiting	2
DB00957	Norgestimate	1	Completed	1
DB05372	Otenabant	1	Completed	1
DB19062	Pegozafermin	1	Completed	1
DB00908	Quinidine	1	Completed	1
DB12914	Resmetirom	1	Completed	1
DB01045	Rifampin	1	Completed	1
DB01098	Rosuvastatin	1	Completed	1
DB15373	Tilmanocept	1	Completed	1
DB00682	Warfarin	1	Completed	1
DB17499	GB1211	1 / 2	Withdrawn	1
DB05123	Gemcabene	1 / 2	Completed	1
DB17695	Heterologous human adult liver derived progenitor cells	1 / 2	Completed	1
DB19062	Pegozafermin	1 / 2	Completed	1
DB00421	Spironolactone	1 / 2	Completed	1
DB16086	Aldafermin	2	Completed	2
DB15024	Apararenone	2	Completed	1
DB01076	Atorvastatin	2	Recruiting	1
DB11758	Cenicriviroc	2	Completed	1
DB19023	Chiglitazar	2	Completed	1
DB00169	Cholecalciferol	2	Completed	1
DB15168	Cilofexor	2	Completed	2
DB15194	Cotadutide	2	Completed	1
DB11672	Curcumin	2	Withdrawn	1
DB18194	Efocipegtrutide	2	Recruiting	1
DB05187	Elafibranor	2	Completed	1
DB12486	Elobixibat	2	Completed	1
DB09038	Empagliflozin	2	Active Not Recruiting	2
DB16166	Firsocostat	2	Completed	2
DB16170	Foralumab	2	Withdrawn	1
DB18214	Ibutamoren	2	Recruiting	1
DB12990	Icosabutate	2	Completed	1
DB00030	Insulin human	2	Completed	3
DB14801	Lanifibranor	2	Active Not Recruiting	1
DB14801	Lanifibranor	2	Completed	1
DB15834	Lecithin	2	Withdrawn	1
DB05941	Leronlimab	2	Completed	1
DB15048	Licogliflozin	2	Terminated	1
DB18031	Linafexor	2	Completed	1
DB16234	Miricorilant	2	Recruiting	1
DB16234	Miricorilant	2	Terminated	1
DB00929	Misoprostol	2	Completed	1
DB12885	Namodenoson	2	Completed	1
DB12885	Namodenoson	2	Recruiting	1
DB16255	Nidufexor	2	Terminated	1
DB05990	Obeticholic acid	2	Completed	1
DB16261	Odevixibat	2	Withdrawn	1
DB05185	Olesoxime	2	Completed	1
DB09539	Omega-3-acid ethyl esters	2	Terminated	1
DB00338	Omeprazole	2	Withdrawn	1
DB06592	Pegargiminase	2	Recruiting	1
DB19062	Pegozafermin	2	Active Not Recruiting	1
DB18998	Pemvidutide	2	Recruiting	1
DB18246	Rencofilstat	2	Active Not Recruiting	1
DB18246	Rencofilstat	2	Completed	1
DB12390	Seladelpar	2	Terminated	1
DB14916	Selonsertib	2	Completed	2
DB12152	Simtuzumab	2	Completed	1
DB18989	Survodutide	2	Completed	1
DB16045	TERN-101	2	Completed	2
DB13946	Testosterone undecanoate	2	Completed	2
DB12647	Tocotrienol	2	Recruiting	1
DB11824	Tofogliflozin	2	Recruiting	1
DB16343	Tropifexor	2	Completed	1
DB16343	Tropifexor	2	Terminated	2
DB15137	VK-2809	2	Completed	1
DB00163	Vitamin E	2	Completed	1
DB00163	Vitamin E	2	Terminated	1
DB15125	Belapectin	2 / 3	Active Not Recruiting	1
DB11860	Aramchol	3	Suspended	1
DB03756	Doconexent	3	Completed	1
DB19012	Efruxifermin	3	Recruiting	1
DB06210	Eltrombopag	3	Terminated	1
DB00783	Estradiol	3	Recruiting	1
DB14801	Lanifibranor	3	Recruiting	1
DB06655	Liraglutide	3	Unknown Status	1
DB05990	Obeticholic acid	3	Terminated	1
DB00806	Pentoxifylline	3	Completed	1
DB12914	Resmetirom	3	Active Not Recruiting	1
DB12914	Resmetirom	3	Recruiting	1
DB18989	Survodutide	3	Recruiting	1
DB11094	Vitamin D	3	Completed	1
DB09045	Dulaglutide	4	Not Yet Recruiting	1
DB09038	Empagliflozin	4	Active Not Recruiting	1
DB09038	Empagliflozin	4	Recruiting	1
DB00973	Ezetimibe	4	Unknown Status	1
DB00166	Lipoic acid	4	Terminated	1
DB00806	Pentoxifylline	4	Completed	1
DB01132	Pioglitazone	4	Recruiting	1
DB00412	Rosiglitazone	4	Terminated	1
DB13928	Semaglutide	4	Active Not Recruiting	1
DB13928	Semaglutide	4	Enrolling by Invitation	1
DB01261	Sitagliptin	4	Enrolling by Invitation	1
DB01586	Ursodeoxycholic acid	4	Completed	1
DB00163	Vitamin E	4	Completed	1
DB05408	Emricasan	Not Available	Completed	1
DB15365	Pegbelfermin	Not Available	Completed	1
DB08869	Tesamorelin	Not Available	Completed	1
DB03904	Urea	Not Available	Recruiting	1
DB09510	Urea C-13	Not Available	Recruiting	1
DB00163	Vitamin E	Not Available	Completed	1