Tramazoline

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Tramazoline is a sympathomimetic indicated for nasal decongestion.

Generic Name
Tramazoline
DrugBank Accession Number
DB13064
Background

Tramazoline is under investigation in clinical trial NCT01601509 (Nasal Tramazoline and Dexamethazone in Obstructive Sleep Apnea (OSA) Patients Tramazoline and).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 215.3
Monoisotopic: 215.142247559
Chemical Formula
C13H17N3
Synonyms
  • Tramazolina
  • Tramazoline

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Symptomatic treatment ofNasal congestion••• ••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololTramazoline may decrease the antihypertensive activities of Acebutolol.
AceclofenacThe risk or severity of hypertension can be increased when Aceclofenac is combined with Tramazoline.
AcemetacinThe risk or severity of hypertension can be increased when Tramazoline is combined with Acemetacin.
Acetylsalicylic acidThe risk or severity of hypertension can be increased when Acetylsalicylic acid is combined with Tramazoline.
AclidiniumThe risk or severity of Tachycardia can be increased when Aclidinium is combined with Tramazoline.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Tramazoline hydrochloride4DG710Q6783715-90-0RZOXEODOFNEZRS-UHFFFAOYSA-N

Categories

ATC Codes
R01AA09 — Tramazoline
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as tetralins. These are polycyclic aromatic compounds containing a tetralin moiety, which consists of a benzene fused to a cyclohexane.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Tetralins
Sub Class
Not Available
Direct Parent
Tetralins
Alternative Parents
Imidazolines / Guanidines / Propargyl-type 1,3-dipolar organic compounds / Carboximidamides / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
2-imidazoline / Aromatic heteropolycyclic compound / Azacycle / Carboximidamide / Guanidine / Hydrocarbon derivative / Organic 1,3-dipolar compound / Organic nitrogen compound / Organoheterocyclic compound / Organonitrogen compound
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
SLE31693IV
CAS number
1082-57-1
InChI Key
QQJLHRRUATVHED-UHFFFAOYSA-N
InChI
InChI=1S/C13H17N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h3,5,7H,1-2,4,6,8-9H2,(H2,14,15,16)
IUPAC Name
N-(5,6,7,8-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine
SMILES
C1CN=C(NC2=CC=CC3=C2CCCC3)N1

References

General References
Not Available
PubChem Compound
5524
PubChem Substance
347829192
ChemSpider
5323
BindingDB
50027056
RxNav
38453
ChEBI
134893
ChEMBL
CHEMBL32573
ZINC
ZINC000001534528
Wikipedia
Tramazoline

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
Not AvailableCompletedTreatmentObstructive Sleep Apnea (OSA)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SprayNasal
SprayNasal1.265 mg/ml
SprayNasal1 MG/ML
SprayNasal
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.408 mg/mLALOGPS
logP2.27ALOGPS
logP2.73Chemaxon
logS-2.7ALOGPS
pKa (Strongest Basic)9.89Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area36.42 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity66.96 m3·mol-1Chemaxon
Polarizability25.05 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-000i-0900000000-ecdcbf55215cfae88eab
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-0090000000-bec4e5811fe866690585
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-03di-2090000000-b5de548959beaa179e11
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-0290000000-9d000e817a6602e3eba8
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-0910000000-a8d808464da792b0c09a
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00yi-7910000000-019c57f839065b0578a9
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-014m-2900000000-22835ab460f393f98436
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-150.21758
predicted
DeepCCS 1.0 (2019)
[M+H]+152.57558
predicted
DeepCCS 1.0 (2019)
[M+Na]+159.33905
predicted
DeepCCS 1.0 (2019)

Drug created at October 21, 2016 02:35 / Updated at June 12, 2021 10:55