Alpha-2B adrenergic receptor

BE0000572ProteinHumansADRA2B

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:11056163, PubMed:2164221, PubMed:2172775, PubMed:23105096, PubMed:26811329). It is acted on by 60 drugs in DrugBank.

Gene name
ADRA2B
UniProtKB entry
P18089Swiss-Prot
Cellular location
Cell membrane
Residues / weight
450 residues · 49,953 Da
Also known as
ADRA2L1 · ADRA2RL1 · Alpha-2 adrenergic receptor subtype C2 · Alpha-2B adrenoceptor · Alpha-2B adrenoreceptor

Resolves to

Protein
UniProtP18089UniProt nameADA2B_HUMAN
Gene
HGNCHGNC:282NCBI Gene151GenBank178198GeneCardsADRA2B
Pharmacology
IUPHAR/GtoPdb26KEGGhsa:151
Structure
PDB6K41PDB6K42
Drugs

What you can answer from here — as of September 07, 2019

60DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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147+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-2B adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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