Alpha-2C adrenergic receptor

BE0000342ProteinHumansADRA2C

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:2842764). It is acted on by 68 drugs in DrugBank.

Gene name
ADRA2C
UniProtKB entry
P18825Swiss-Prot
Cellular location
Cell membrane
Residues / weight
462 residues · 49,522 Da
Also known as
ADRA2L2 · ADRA2RL2 · Alpha-2 adrenergic receptor subtype C4 · Alpha-2C adrenoceptor · Alpha-2C adrenoreceptor

Resolves to

Protein
UniProtP18825UniProt nameADA2C_HUMAN
Gene
HGNCHGNC:283NCBI Gene152GenBank178194GeneCardsADRA2C
Pharmacology
IUPHAR/GtoPdb27KEGGhsa:152
Structure
PDB6KUW
Drugs

What you can answer from here — as of September 07, 2019

68DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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147+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-2C adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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