Alpha-2A adrenergic receptor

BE0000289ProteinHumansADRA2A

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:2170371, PubMed:23105096, PubMed:2568356, PubMed:35245122, PubMed:27376152). It is acted on by 82 drugs in DrugBank.

Gene name
ADRA2A
UniProtKB entry
P08913Swiss-Prot
Cellular location
Cell membrane
Residues / weight
465 residues · 50,646 Da
Also known as
ADRA2R · ADRAR · Alpha-2 adrenergic receptor subtype C10 · Alpha-2A adrenoceptor · Alpha-2A adrenoreceptor

Resolves to

Protein
UniProtP08913UniProt nameADA2A_HUMAN
Gene
HGNCHGNC:281NCBI Gene150GenBank178196GeneCardsADRA2A
Pharmacology
IUPHAR/GtoPdb25KEGGhsa:150
Structure
PDB1HLLPDB1HO9PDB1HOD
Drugs

What you can answer from here — as of September 07, 2019

82DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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268+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-2A adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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