Acemetacin is a NSAID indicated in the treatment of pain and inflammation. Acemetacin is a carboxymethyl ester of indometacin.
- Mechanism
- Curator reviewed · 2 references
Acemetacin is a non-selective inhibitor of the production of pro-inflammatory mediators derived from the action of the enzyme COX. COX is essential for the synthesis of prostaglandin E2 and F2 which are molecules derived from fatty acids and stored in the cell membrane. Acetometacine is metabolized and forms its major metabolite indometacin which is also a non-selective inhibitor of COX and exhibits the capacity to inhibit the motility of polymorphonuclear leukocytes and decreased cerebral flow by modulating the nitric oxide pathway and vasoconstriction.
- Primary indication
- Acemetacin is not FDA, Canada or EMA approved, but in the countries where it is marketed it is indicated for the symptomatic treatment of pain and swelling in acute inflammation of the joints in rheumathoid...Curator reviewed · 1 structured indication
- Formula / weight
- C21H18ClNO6 · 415.83 g/mol (avg)
- Also known as
- indometacin carboxymethyl ester · indometacin glycolic ester · indomethacin carboxymethyl ester · indomethacin glycolic ester
- Code names
- K-708 · TV-1322 · TVX 3322
Resolves to
FSQKKOOTNAMONP-UHFFFAOYSA-NSMILESCOC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(=O)OCC(O)=OWhat you can answer from here — as of June 19, 2026
Which drugs share a target with Acemetacin, and which of those have an active Phase 3 trial?
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