ATP-binding cassette sub-family C member 1

BE0000785ProteinHumansABCC1

ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. It is acted on by 82 drugs in DrugBank.

Gene name
ABCC1
UniProtKB entry
P33527Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,531 residues · 171,590 Da
Also known as
7.6.2.- · Glutathione-S-conjugate-translocating ATPase ABCC1 · Leukotriene C(4) transporter · LTC4 transporter · MRP

Resolves to

Protein
UniProtP33527UniProt nameMRP1_HUMAN
Gene
HGNCHGNC:51NCBI Gene4363GenBank1835659GeneCardsABCC1
Pharmacology
IUPHAR/GtoPdb779KEGGhsa:4363
Structure
PDB2CBZPDB4C3ZPDB8VT4
Drugs

What you can answer from here — as of September 08, 2026

82DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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35GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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212+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 1, how selective are they, and which programs against it are still in active trials?

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