PZM21

DB14030ExperimentalSmall molecule

PZM21 is a novel μ-opioid receptor (MOPr) ligand that has been reported to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects characteristic of classical μ-opioid ligands...

Mechanism: Pharmacologically active on Mu-type opioid receptor
Curator reviewed
Formula / weight: C₁₉H₂₇N₃O₂S · 361.5 g/mol (avg)
Code names: PZM21

Resolves to

Compound

UNIIM8GB23F27ECAS1997387-43-5

Structure

InChIKeyMEDBIJOVZJEMBI-YOEHRIQHSA-NSMILESC[C@@H](CC1=CSC=C1)NC(=O)NC[C@H](CC1=CC=C(O)C=C1)N(C)C

Targets

P35372OPRM1

What you can answer from here — as of July 07, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with PZM21, and which of those have an active Phase 3 trial?

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