GDC-0927

DB14934InvestigationalSmall molecule

GDC-0927 is under investigation in clinical trial NCT02316509 (A Study of GDC-0927 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive Breast Cancer).

Mechanism: Pharmacologically active on Estrogen receptor
Curator reviewed
Formula / weight: C₂₈H₂₈FNO₄ · 461.533 g/mol (avg)
Code names: GDC-0927

Resolves to

Compound

UNIIST9B0EMC0HCAS2100830-77-9

Structure

InChIKeyKJAAPZIFCQQQKX-NDEPHWFRSA-NSMILESCC1=C([C@@H](OC2=CC=C(O)C=C12)C1=CC=C(OCCN2CC(CF)C2)C=C1)C1=CC(O)=CC=C1

Targets

P03372ESR1

What you can answer from here — as of October 21, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with GDC-0927, and which of those have an active Phase 3 trial?

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