This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Cimlanod
DrugBank Accession Number
DB14983
Background

Cimlanod is under investigation in clinical trial NCT02819271 (A First-in-Human Study of the Safety of Single Continuous Intravenous (IV) Infusions of CXL-1427 for up to 48 Hours in Healthy Volunteers).

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 177.17
Monoisotopic: 177.009578883
Chemical Formula
C5H7NO4S
Synonyms
  • BMS-986231
  • Cimlanod

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
2US4FK1EPV
CAS number
1620330-72-4
InChI Key
LIXKIXWSKOENAB-UHFFFAOYSA-N
InChI
InChI=1S/C5H7NO4S/c1-4-2-3-5(10-4)11(8,9)6-7/h2-3,6-7H,1H3
IUPAC Name
N-hydroxy-5-methylfuran-2-sulfonamide
SMILES
CC1=CC=C(O1)S(=O)(=O)NO

References

General References
Not Available
ChemSpider
68007456
ZINC
ZINC000145617689
Wikipedia
Cimlanod

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentAcute Heart Failure (AHF) / Decompensated Heart Failure / Heart Failure1
2CompletedTreatmentCardiac Failure / Congestive Heart Failure (CHF) / Decompensation, Heart / Myocardial Failure1
2CompletedTreatmentCardiac Failure / Heart Failure / Reduced Ventricular Ejection Fraction1
2CompletedTreatmentHeart Failure1
1CompletedTreatmentCardiac Failure / Congestive Heart Failure (CHF) / Decompensation, Heart / Hepatic dysfunction / Hepatic Failure / Liver Insufficiency / Myocardial Failure1
1CompletedTreatmentCardiac Failure / Congestive Heart Failure (CHF) / Kidney Failure / Myocardial Failure1
1CompletedTreatmentHeart Decompensation, Acute2
1CompletedTreatmentHeart Failure2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility7.12 mg/mLALOGPS
logP0.14ALOGPS
logP0.0052ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)7.93ChemAxon
pKa (Strongest Basic)-3.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area79.54 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity36.9 m3·mol-1ChemAxon
Polarizability15.69 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:39 / Updated at February 21, 2021 18:55