NOP-1A

DB15208InvestigationalSmall molecule

NOP-1A is under investigation in clinical trial NCT01198197 (PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A).

Mechanism: Pharmacologically active on Nociceptin receptor
Curator reviewed
Formula / weight: C₂₂H₂₆F₂N₂O₂S · 420.52 g/mol (avg)

Resolves to

Compound

UNIIDQY244459TCAS1283095-70-4ChEMBLCHEMBL2088033

Structure

InChIKeyMZBCQWLYUQJXKA-KRWDZBQOSA-NSMILESCNC(=O)[C@H](CN1CCC2(CC1)OCCC1=C2SC(F)=C1)CC1=CC=CC=C1F

Targets

P41146OPRL1

What you can answer from here — as of July 08, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with NOP-1A, and which of those have an active Phase 3 trial?

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