This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Glumetinib
- DrugBank Accession Number
- DB15630
- Background
Glumetinib is under investigation in clinical trial NCT04270591 (Assess the Anti-tumor Activity and Safety of Glumetinib in Patient With Advanced C-met-positive Non-small Cell Lung Cancer).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Glumetinib (DB15630)
- Weight
- Average: 459.49
Monoisotopic: 459.122591997 - Chemical Formula
- C21H17N9O2S
- Synonyms
- 6-(1-methyl-1h-pyrazol-4-yl)-1-((6-(1-methyl-1h-pyrazol-4-yl)imidazo(1,2-a)pyridin-3-yl)sulfonyl)-1h-pyrazolo(4,3-b)pyridine
- External IDs
- SC-C244
- SCC244
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7JTT036WGX
- CAS number
- 1642581-63-2
- InChI Key
- RYBLECYFLJXEJX-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H17N9O2S/c1-27-11-16(7-24-27)14-3-4-20-23-10-21(29(20)13-14)33(31,32)30-19-5-15(6-22-18(19)9-26-30)17-8-25-28(2)12-17/h3-13H,1-2H3
- IUPAC Name
- 1-methyl-4-(3-{[6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridin-1-yl]sulfonyl}imidazo[1,2-a]pyridin-6-yl)-1H-pyrazole
- SMILES
- CN1C=C(C=N1)C1=CN2C(C=C1)=NC=C2S(=O)(=O)N1N=CC2=NC=C(C=C12)C1=CN(C)N=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 68006902
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 1 Completed Health Services Research Healthy Subjects (HS) 1 1 Unknown Status Treatment Advanced Solid Tumors 2 1, 2 Recruiting Treatment C-Met Exon 14 Mutation 1 1, 2 Recruiting Treatment Relapsed or Metastatic Non-small Cell Lung Cancer 1 1, 2 Unknown Status Treatment Negative T790M Mutation and Met Amplification 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.511 mg/mL ALOGPS logP 2.14 ALOGPS logP 0.42 Chemaxon logS -3 ALOGPS pKa (Strongest Basic) 3.06 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 117.79 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 143.78 m3·mol-1 Chemaxon Polarizability 45.89 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at March 07, 2020 20:04 / Updated at June 12, 2020 16:53