Adipose mesenchymal stem cells (AMSCs) are MSCs derived from adipose tissue, which is more accessible and less painful than stem cells extracted from most other sources. Autologous stem cells are... Autologous stem cells are those derived from a patient’s own cells while allogeneic stem cells are derived from that of a donor.
- Mechanism
- Curator reviewed
AMSCs have been shown to secrete several growth factors and hyaluronic acid (HA) which balance collagen, with hepatocyte growth factor (HGF) being a major part of those secreted. HGF secreted by AMSCs has been shown, in culture, to attenuate collagen production and fibroblast proliferation. AMSCs also have the ability to produce elastic fibers, something that typically does not appear in a scar environment.
In some studies, adipose mesenchymal stem cells have demonstrated anti-inflammatory and chondroprotective properties. Currently, the exact mechanism behind AMSCs is unknown. However, a possible mechanism consists of activation of the cells due to inflammation, with the activated cells then modulating inflammation and cartilage remodeling by prostaglandin E2. The effects for AMSCs seem to also possibly be dose-dependent.
- Also known as
- adMSC · AstroStem-V · CMTAd · HB-adMSCs · HCR040
Resolves to
What you can answer from here — as of April 23, 2025
Which companies are running trials of Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins, in which indications and phases, and which of those programs are still active?
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