ORBCEL-C™ is the trade name of a product composed of highly purified stromal cells derived from the human umbilical cord. The isolated cells are expanded in culture and are able... The isolated cells are expanded in culture and are able to be used allogenically -- meaning that one donor’s cells can be given to other unrelated patients.
- Mechanism
- Curator reviewed
The mesenchymal stem cells (MSCs) of ORBCEL-C™ act through release of factors which reduce inflammatory responses, promote blood vessel formation, and have the ability to demonstrate immunomodulatory effects.
Allogeneic UC-MSCs are also being investigated in orthopedic applications for cartilage and bone regeneration; these UC-MSCs are a valuable allogeneic source of cells as these cells are from a discarded material with virtually unlimited availability. Specifically to orthopedics, UC-MSCs have potential for treatment of chondral and osteochondral lesions, and bone defects as a universal off-the-shelf product.
- Also known as
- Allogeneic donor CD362 enriched human umbilical cord-derived mesenchymal stromal cells · ORBCEL C™ · Orbcel-C · REALIST ORBCEL-C
- Code names
- Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells
What you can answer from here — as of August 13, 2020
Which companies are running trials of Allogenic donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells, in which indications and phases, and which of those programs are still active?
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