Stem cells are self-renewing and proliferate without differentiation, with the two major groups being embryonic stem cells (ESCs) and adult stem cells (ASC). Differentiation occurs under different conditions into different... ESCs are from the inner cell mass of blastocysts while ASCs are deposited into adult tissues with restricted differentiation potency but also a lack of tumorigenicity.
- Mechanism
- Curator reviewed
Mesenchymal stem cells have applications in research, therapeutic, and regenerative purposes. Similarly, MenSCs have previously demonstrated their ability to differentiate into adipocytes, cardiomyocytes, chondrocytes, hepatocytes, osteocytes, and pancreatic cells. Additionally, MenSCs express both pluripotency markers and mesenchymal stem cell-specific markers as well, making them potentially useful for research on differentiation and in regenerative medicine. MenSCs have also been shown to both induce and inhibit proliferation of natural killer (NK) cells, with inhibition occurring if the MenSCs were pre-treated with IFN-γ/IL-1β. Additionally, MenSCs can inhibit optimal maturation of monocyte-derived dendritic cells, and depending on the cell concentration, either stimulate or inhibit an allogeneic mixed lymphocyte reaction.
- Also known as
- MenSCs
- Code names
- Human Menstrual Blood-derived Stem Cells
What you can answer from here — as of August 13, 2020
Which companies are running trials of Human Menstrual Blood-derived Stem Cells, in which indications and phases, and which of those programs are still active?
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