Identification
- Generic Name
- Human Menstrual Blood-derived Stem Cells
- DrugBank Accession Number
- DB15738
- Background
Stem cells are self-renewing and proliferate without differentiation, with the two major groups being embryonic stem cells (ESCs) and adult stem cells (ASC). Differentiation occurs under different conditions into different cell types. ESCs are from the inner cell mass of blastocysts while ASCs are deposited into adult tissues with restricted differentiation potency but also a lack of tumorigenicity. Menstrual blood-derived stem cells (MenSCs) are mesenchymal-like ASCs which are non-invasively derived from menstrual blood from the shed endometrium of a human female. These cells possess a high rate of proliferation and multi-lineage differentiation potency.
MenSCs are special compared to older methods of adult stem cell extraction such as bone marrow stem cell extraction because MenSC extraction is a non-invasive method. Because this is a non-invasive way to obtain stem cells, it is simple and easy to obtain the stem cells with an absence of ethical issues that may come from obtaining stem cells of the embryonic kind.
- Type
- Biotech
- Groups
- Investigational
- Biologic Classification
- Cell transplant therapies
Other cell transplant therapies - Synonyms
- MenSCs
- External IDs
- Human Menstrual Blood-derived Stem Cells
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
Mesenchymal stem cells have applications in research, therapeutic, and regenerative purposes. Similarly, MenSCs have previously demonstrated their ability to differentiate into adipocytes, cardiomyocytes, chondrocytes, hepatocytes, osteocytes, and pancreatic cells. Additionally, MenSCs express both pluripotency markers and mesenchymal stem cell-specific markers as well, making them potentially useful for research on differentiation and in regenerative medicine. MenSCs have also been shown to both induce and inhibit proliferation of natural killer (NK) cells, with inhibition occurring if the MenSCs were pre-treated with IFN-γ/IL-1β. Additionally, MenSCs can inhibit optimal maturation of monocyte-derived dendritic cells, and depending on the cell concentration, either stimulate or inhibit an allogeneic mixed lymphocyte reaction.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
References
- General References
- Shokri MR, Bozorgmehr M, Ghanavatinejad A, Falak R, Aleahmad M, Kazemnejad S, Shokri F, Zarnani AH: Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells. Sci Rep. 2019 Jul 10;9(1):10007. doi: 10.1038/s41598-019-46316-3. [Article]
- Faramarzi H, Mehrabani D, Fard M, Akhavan M, Zare S, Bakhshalizadeh S, Manafi A, Kazemnejad S, Shirazi R: The Potential of Menstrual Blood-Derived Stem Cells in Differentiation to Epidermal Lineage: A Preliminary Report. World J Plast Surg. 2016 Jan;5(1):26-31. [Article]
- External Links
- Not Available
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Female Infertility / Poor Ovarian Response 1 1, 2 Unknown Status Treatment Cirrhosis of the Liver / Digestive System Diseases / Fibrosis / Liver Disease 1 1, 2 Unknown Status Treatment Type 1 Diabetes Mellitus 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at August 11, 2020 20:47 / Updated at August 13, 2020 07:02