Glycine receptor subunit alpha-2

BE0000745ProteinHumansGLRA2

Subunit of heteromeric glycine-gated chloride channels (PubMed:15302677, PubMed:16144831, PubMed:2155780, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). It is acted on by 13 drugs in DrugBank.

Gene name
GLRA2
UniProtKB entry
P23416Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
452 residues · 52,002 Da

Resolves to

Protein
UniProtP23416UniProt nameGLRA2_HUMAN
Gene
HGNCHGNC:4327NCBI Gene2742GenBank31849GeneCardsGLRA2
Pharmacology
IUPHAR/GtoPdb424KEGGhsa:2742
Structure
PDB5BKFPDB5BKGPDB7KUY
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycine receptor subunit alpha-2, how selective are they, and which programs against it are still in active trials?

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