Glycine receptor subunit alpha-1

BE0000433ProteinHumansGLRA1

Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). It is acted on by 30 drugs in DrugBank.

Gene name
GLRA1
UniProtKB entry
P23415Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
457 residues · 52,623 Da
Also known as
Glycine receptor 48 kDa subunit · Glycine receptor strychnine-binding subunit

Resolves to

Protein
UniProtP23415UniProt nameGLRA1_HUMAN
Gene
HGNCHGNC:4326NCBI Gene2741GenBank31851GeneCardsGLRA1
Pharmacology
IUPHAR/GtoPdb423KEGGhsa:2741
Structure
PDB1MOTPDB1VRYPDB2M6B
Drugs

What you can answer from here — as of September 07, 2019

30DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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61+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycine receptor subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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