Bromodomain-containing protein 4

BE0010747ProteinHumansBRD4

Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation (PubMed:20871596, PubMed:23086925, PubMed:23317504, PubMed:29176719, PubMed:29379197). It is acted on by 17 drugs in DrugBank.

Gene name
BRD4
UniProtKB entry
O60885Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,362 residues · 152,218 Da
Also known as
HUNK1 · Protein HUNK1

Resolves to

Protein
UniProtO60885UniProt nameBRD4_HUMAN
Gene
HGNCHGNC:13575NCBI Gene23476GeneCardsBRD4
Pharmacology
IUPHAR/GtoPdb1945KEGGhsa:23476
Structure
PDB2I8NPDB2LSPPDB2MJV
Drugs

What you can answer from here — as of October 31, 2023

17DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
22GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
40+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Bromodomain-containing protein 4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In