- Accession Number
Six-membered heterocycles containing an oxygen and a nitrogen.
Drug Drug Description Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Ifosfamide An alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Rivaroxaban A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. Viltolarsen An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping. Reboxetine A drug used for the acute treatment of major depression and for maintenance therapy of depression. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Moricizine An antiarrhythmic used to treat arrhythmias. Phenmetrazine Used as an anorectic in the treatment of obesity. Dextromoramide An opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070) Phendimetrazine A sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity. Mdl 101,146 Not Available LY-294002 Specific inhibitor of phosphatidylinositol 3-kinase. 3-(N-morpholino)propanesulfonic acid Not Available 2-(N-morpholino)ethanesulfonic acid Not Available Tanaproget Tanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most... APD791 For the treatment and prophylaxis of arterial thrombosis. Canertinib Investigated for use/treatment in breast cancer and lung cancer. Apilimod Investigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders. Palifosfamide Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma. Eteplirsen An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 51 skipping. Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Glufosfamide Investigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma. Cetilistat Investigated for use/treatment in obesity. Quarfloxin Investigated for use/treatment in leukemia (lymphoid). Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy. Reversine Not Available Fominoben Fominoben is an antitussive agent. Amorolfine A morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis. Olodaterol A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Edivoxetine Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment.... Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Lubazodone Lubazodone (YM-992, YM-35,995) is an arylpiperazine antidepressant which was being developed as a treatment for depression and obsessive compulsive disorder, and reached phase II clinical trials, but was discontinued. It... Pholcodine An opioid antitussive used to suppress unproductive coughing. Molsidomine A long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction. Pramocaine A local anesthetic and antipruritic agent found in various topical preparations. Buparlisib Buparlisib has been used in trials studying the treatment and basic science of Lymphoma, Metastases, Lung Cancer, Solid Tumors, and Breast Cancer, among others. Mosapride A prokinetic 5-HT4 receptor agonist used to stimulate gastric motility. GSK-2636771 GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others. Basmisanil Basmisanil has been used in trials studying the treatment and basic science of Down Syndrome. Fimepinostat Fimepinostat (CUDC-907) has been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and NUT midline carcinoma, among others. Gedatolisib Gedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others. Vistusertib Vistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma. Epelsiban Epelsiban has been investigated for the treatment of Premature Ejaculation. Fostamatinib A spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment. Iberdomide Iberdomide (CC-220) has been used in trials studying the treatment of Systemic Lupus Erythematosus. Landiolol An ultra short-acting selective beta-blocker used for rapid ventricular rate control in cases of supraventricular tachycardia. Esreboxetine Esreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia. Rimacalib Rimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA). AZD-8055 AZD8055 has been used in trials studying the treatment of Cancer, Lymphomas, Solid Tumors, MALIGNANT GLIOMA, and brainstem glioma, among others. Zoliflodacin Zoliflodacin has been used in trials studying the basic science and treatment of Gonorrhoea. Tazemetostat A methyltransferase inhibitor indicated to treat patients 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. VS-5584 VS-5584 has been used in trials studying the treatment of Lymphoma, Metastatic Cancer, and Non Hematologic Cancers. Apratastat Tmi 005 is under investigation in clinical trial NCT00095342 (Study Evaluating TMI-005 in Active Rheumatoid Arthritis). PKI-179 PKI-179 has been used in trials studying the treatment of Advanced Malignant Solid Tumors. Linsidomine Not Annotated Oxaflozane Not Annotated Moroxydine Not Annotated Tiemonium iodide Not Annotated Morpholine Not Annotated Xamoterol Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but... WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Baloxavir marboxil A polymerase acidic endonuclease inhibitor used to treat uncomplicated influenza. Morpholinylmercaptobenzothiazole Not Annotated SUVN-G3031 SUVN-G3031 is under investigation in clinical trial NCT02342041 (A Study to Investigate the Safety, Tolerability and Pharmacokinetics of SUVN-G3031 in Healthy Subjects). Ceralasertib Ceralasertib is under investigation in clinical trial NCT03682289 (Phase II Trial of AZD6738 Alone and in Combination With Olaparib). Satavaptan Satavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver). Serabelisib Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117)... Pemigatinib A kinase inhibitor used to treat locally advanced or metastatic, unresectable cholangiocarcinoma in previously treated adult patients. Radavirsen Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza). Baloxavir Baloxavir is under investigation in clinical trial NCT04327791 (Combination Therapy With Baloxavir and Oseltamavir 1 for Hospitalized Patients With Influenza (The COMBO Trial 1)). KZR-616 KZR-616 is under investigation in clinical trial NCT04033926 (A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis). Aclimostat Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes). ASTX660 ASTX660 is under investigation in clinical trial NCT02503423 (Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas). Lazertinib Lazertinib is under investigation in clinical trial NCT04487080 (A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-small Cell Lung Cancer). E-52862 Not Annotated PD-173952 PD-173952 is a potent Myt1 kinase inhibitor. KX-2361 Not Annotated
- Drugs & Drug Targets