- Accession Number
Six-membered heterocycles containing an oxygen and a nitrogen.
Drug Drug Description Reboxetine For the treatment of clinical depression. Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Efavirenz A non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. Moricizine An antiarrhythmic used to treat arrhythmias. Phenmetrazine Used as an anorectic in the treatment of obesity. Ifosfamide An alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma. Dextromoramide An opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070) Phendimetrazine A sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity. Mdl 101,146 Not Available LY-294002 Specific inhibitor of phosphatidylinositol 3-kinase. Tanaproget Tanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most... APD791 For the treatment and prophylaxis of arterial thrombosis. Canertinib Investigated for use/treatment in breast cancer and lung cancer. Apilimod Investigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders. Palifosfamide Investigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma. Glufosfamide Investigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma. Rivaroxaban A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations. Cetilistat Investigated for use/treatment in obesity. Quarfloxin Investigated for use/treatment in leukemia (lymphoid). Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy. Fominoben Fominoben is an antitussive agent. Amorolfine Amorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol... Olodaterol A long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Edivoxetine Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment.... Viloxazine Indicated for the treatment of clinical depression. Lubazodone Lubazodone (YM-992, YM-35,995) is an arylpiperazine antidepressant which was being developed as a treatment for depression and obsessive compulsive disorder, and reached phase II clinical trials, but was discontinued. It... Pholcodine Pholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."... Molsidomine The indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension [L1370, L1371]. Pramocaine A local anesthetic and antipruritic agent found in various topical preparations. Buparlisib Buparlisib has been used in trials studying the treatment and basic science of Lymphoma, Metastases, Lung Cancer, Solid Tumors, and Breast Cancer, among others. Mosapride Mosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). Mosapride has been investigated for the treatment and diagnostic of Constipation, Type... CUDC-907 CUDC-907 has been used in trials studying the treatment of Lymphoma, Solid Tumors, BREAST CANCER, Multiple Myeloma, and NUT Midline Carcinoma, among others. Gedatolisib Gedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others. Vistusertib Vistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma. Epelsiban Epelsiban has been investigated for the treatment of Premature Ejaculation. Landiolol Landiolol has been used in trials studying the treatment of Pharmacokinetics/Dynamics Study. Esreboxetine Esreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia. AZD-8055 AZD8055 has been used in trials studying the treatment of Cancer, Lymphomas, Solid Tumors, MALIGNANT GLIOMA, and brainstem glioma, among others. VS-5584 VS-5584 has been used in trials studying the treatment of Lymphoma, Metastatic Cancer, and Non Hematologic Cancers. Apratastat Tmi 005 is under investigation in clinical trial NCT00095342 (Study Evaluating TMI-005 in Active Rheumatoid Arthritis). PKI-179 PKI-179 has been used in trials studying the treatment of Advanced Malignant Solid Tumors. Linsidomine Not Annotated Oxaflozane Not Annotated Moroxydine Not Annotated Tiemonium iodide Not Annotated Morpholine Not Annotated Xamoterol Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but... WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Morpholinylmercaptobenzothiazole Not Annotated Satavaptan Satavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver). Eteplirsen An antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation. GSK-2636771 GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others. Rimacalib Rimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA). Serabelisib Serabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117)... Radavirsen Radavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza). Reversine Not Available 3-(N-morpholino)propanesulfonic acid Not Available 2-(N-morpholino)ethanesulfonic acid Not Available Viltolarsen An antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations. Aclimostat Aclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes). Casimersen An antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping.
- Drugs & Drug Targets