Accession Number

Six-membered heterocycles containing an oxygen and a nitrogen.

DrugDrug Description
ReboxetineA drug used for the acute treatment of major depression and for maintenance therapy of depression.
TimololA non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.
EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
MoricizineAn antiarrhythmic used to treat arrhythmias.
PhenmetrazineUsed as an anorectic in the treatment of obesity.
IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
DextromoramideAn opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
PhendimetrazineA sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity.
Mdl 101,146Not Available
LY-294002Specific inhibitor of phosphatidylinositol 3-kinase.
TanaprogetTanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most...
APD791For the treatment and prophylaxis of arterial thrombosis.
CanertinibInvestigated for use/treatment in breast cancer and lung cancer.
ApilimodInvestigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders.
PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
CetilistatInvestigated for use/treatment in obesity.
QuarfloxinInvestigated for use/treatment in leukemia (lymphoid).
FosaprepitantAn antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy.
FominobenFominoben is an antitussive agent.
AmorolfineA morpholine derivative commonly applied as a lacquer for onychomycosis but is also used for superficial dermatomycosis.
OlodaterolA long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
EdivoxetineEdivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment....
ViloxazineIndicated for the treatment of clinical depression.
LubazodoneLubazodone (YM-992, YM-35,995) is an arylpiperazine antidepressant which was being developed as a treatment for depression and obsessive compulsive disorder, and reached phase II clinical trials, but was discontinued. It...
PholcodineAn opioid antitussive used to suppress unproductive coughing.
MolsidomineA long-acting vasodilator used to treat angina pectoris, including in association with left heart failure and acute myocardial infarction.
PramocaineA local anesthetic and antipruritic agent found in various topical preparations.
BuparlisibBuparlisib has been used in trials studying the treatment and basic science of Lymphoma, Metastases, Lung Cancer, Solid Tumors, and Breast Cancer, among others.
MosaprideA prokinetic 5-HT4 receptor agonist used to stimulate gastric motility.
CUDC-907CUDC-907 has been used in trials studying the treatment of Lymphoma, Solid Tumors, BREAST CANCER, Multiple Myeloma, and NUT Midline Carcinoma, among others.
GedatolisibGedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others.
VistusertibVistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma.
EpelsibanEpelsiban has been investigated for the treatment of Premature Ejaculation.
LandiololAn ultra short-acting selective beta-blocker used for rapid ventricular rate control in cases of supraventricular tachycardia.
EsreboxetineEsreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia.
AZD-8055AZD8055 has been used in trials studying the treatment of Cancer, Lymphomas, Solid Tumors, MALIGNANT GLIOMA, and brainstem glioma, among others.
VS-5584VS-5584 has been used in trials studying the treatment of Lymphoma, Metastatic Cancer, and Non Hematologic Cancers.
ApratastatTmi 005 is under investigation in clinical trial NCT00095342 (Study Evaluating TMI-005 in Active Rheumatoid Arthritis).
PKI-179PKI-179 has been used in trials studying the treatment of Advanced Malignant Solid Tumors.
LinsidomineNot Annotated
OxaflozaneNot Annotated
MoroxydineNot Annotated
Tiemonium iodideNot Annotated
MorpholineNot Annotated
XamoterolXamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but...
WIN 55212-2WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It...
MorpholinylmercaptobenzothiazoleNot Annotated
SatavaptanSatavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver).
EteplirsenAn antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation.
GSK-2636771GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others.
RimacalibRimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA).
SerabelisibSerabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117)...
RadavirsenRadavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).
ReversineNot Available
3-(N-morpholino)propanesulfonic acidNot Available
2-(N-morpholino)ethanesulfonic acidNot Available
ViltolarsenAn antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations.
AclimostatAclimostat is under investigation in clinical trial NCT03254368 (Study to Assess the Effects and Safety of ZGN-1061 in Overweight and Obese Participants With Type 2 Diabetes).
CasimersenAn antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping.
Drugs & Drug Targets
ReboxetineSodium-dependent noradrenaline transportertarget
ReboxetineCytochrome P450 3A4enzyme
ReboxetineCytochrome P450 2D6enzyme
ReboxetineP-glycoprotein 1transporter
TimololBeta-1 adrenergic receptortarget
TimololBeta-2 adrenergic receptortarget
TimololCytochrome P450 2D6enzyme
TimololP-glycoprotein 1transporter
TimololCytochrome P450 2C19enzyme
EfavirenzCytochrome P450 2B6enzyme
EfavirenzCytochrome P450 3A4enzyme
EfavirenzCytochrome P450 2C19enzyme
EfavirenzCytochrome P450 2C9enzyme
EfavirenzCytochrome P450 1A2enzyme
EfavirenzCytochrome P450 2D6enzyme
EfavirenzReverse transcriptase/RNaseHtarget
EfavirenzCytochrome P450 2C8enzyme
EfavirenzSerum albumincarrier
EfavirenzCytochrome P450 3A5enzyme
EfavirenzCytochrome P450 3A7enzyme
EfavirenzUDP-glucuronosyltransferase 1-1enzyme
EfavirenzBile salt export pumptransporter
EfavirenzSolute carrier family 22 member 1transporter
AprepitantNeurokinin 1 receptortarget
AprepitantCytochrome P450 3A4enzyme
AprepitantCytochrome P450 2C9enzyme
AprepitantCytochrome P450 2C19enzyme
MoricizineSodium channel protein type 5 subunit alphatarget
PhenmetrazineSodium-dependent noradrenaline transportertarget
PhenmetrazineSodium-dependent dopamine transportertarget
IfosfamideCytochrome P450 2B6enzyme
IfosfamideCytochrome P450 3A4enzyme
IfosfamideCytochrome P450 3A5enzyme
IfosfamideCytochrome P450 2C9enzyme
IfosfamideCytochrome P450 2C8enzyme
IfosfamideCytochrome P450 2A6enzyme
IfosfamideCytochrome P450 2C19enzyme
IfosfamideCytochrome P450 2C18enzyme
IfosfamideProstaglandin G/H synthase 1enzyme
IfosfamideNuclear receptor subfamily 1 group I member 2target
PhendimetrazineAlpha-1A adrenergic receptortarget
PhendimetrazineAlpha-1B adrenergic receptortarget
PhendimetrazineSodium-dependent noradrenaline transportertarget
Mdl 101,146Chymotrypsin-like elastase family member 1target
Mdl 101,146Neutrophil elastasetarget
LY-294002Serine/threonine-protein kinase pim-1target
LY-294002Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
TanaprogetProgesterone receptortarget
APD7915-hydroxytryptamine receptor 2Atarget
CanertinibEpidermal growth factor receptortarget
PalifosfamideDNA (cytosine-5)-methyltransferase 1target
RivaroxabanCoagulation factor Xtarget
RivaroxabanCytochrome P450 3A4enzyme
RivaroxabanCytochrome P450 2J2enzyme
RivaroxabanP-glycoprotein 1transporter
RivaroxabanCytochrome P450 3A5enzyme
RivaroxabanATP-binding cassette sub-family G member 2transporter
CetilistatPancreatic triacylglycerol lipasetarget
FosaprepitantCytochrome P450 3A4enzyme
FosaprepitantCytochrome P450 2C9enzyme
OlodaterolBeta-2 adrenergic receptortarget
OlodaterolCytochrome P450 2C9enzyme
OlodaterolCytochrome P450 2C8enzyme
PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
PinaveriumCytochrome P450 3A4enzyme
ViloxazineSodium-dependent noradrenaline transportertarget
ViloxazineCytochrome P450 1A2enzyme
PholcodineMu-type opioid receptortarget
PholcodineKappa-type opioid receptortarget
PholcodineDelta-type opioid receptortarget
MolsidomineGuanylate cyclase soluble subunit alpha-2target
MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
PramocaineVoltage-gated sodium channel alpha subunittarget
LandiololCytochrome P450 2D6enzyme
XamoterolBeta-1 adrenergic receptortarget
WIN 55212-2Cytochrome P450 3A4enzyme
EteplirsenDMD-001 gene (exon 51 target site)target
ReversineAurora kinase Btarget
ReversineInner centromere proteintarget
3-(N-morpholino)propanesulfonic acidPhosphoribosylglycinamide formyltransferase 2target
3-(N-morpholino)propanesulfonic acidAlpha-xylosidasetarget
3-(N-morpholino)propanesulfonic acidGranulysintarget
2-(N-morpholino)ethanesulfonic acidChymasetarget
2-(N-morpholino)ethanesulfonic acidGlutathione S-transferase Ptarget
2-(N-morpholino)ethanesulfonic acidAcetylcholinesterasetarget
2-(N-morpholino)ethanesulfonic acidGlutamine--fructose-6-phosphate aminotransferase [isomerizing]target
2-(N-morpholino)ethanesulfonic acidDihydrofolate reductasetarget
2-(N-morpholino)ethanesulfonic acidCopper-containing nitrite reductasetarget
2-(N-morpholino)ethanesulfonic acidCorticosteroid 11-beta-dehydrogenase isozyme 1target
2-(N-morpholino)ethanesulfonic acidHydroxylamine reductasetarget
2-(N-morpholino)ethanesulfonic acidDiaminopimelate decarboxylasetarget
2-(N-morpholino)ethanesulfonic acidAlpha-xylosidasetarget
2-(N-morpholino)ethanesulfonic acidLimonene-1,2-epoxide hydrolasetarget
2-(N-morpholino)ethanesulfonic acidMannan endo-1,4-beta-mannosidasetarget
2-(N-morpholino)ethanesulfonic acidBeta-1,4-galactosyltransferase 1target
2-(N-morpholino)ethanesulfonic acidTyrosine-protein kinase transforming protein Abltarget
2-(N-morpholino)ethanesulfonic acidBifunctional protein GlmUtarget
2-(N-morpholino)ethanesulfonic acidThiol:disulfide interchange protein DsbCtarget
2-(N-morpholino)ethanesulfonic acidGlyceraldehyde-3-phosphate dehydrogenase Atarget
2-(N-morpholino)ethanesulfonic acid(S)-mandelate dehydrogenasetarget
2-(N-morpholino)ethanesulfonic acidDissimilatory copper-containing nitrite reductasetarget
2-(N-morpholino)ethanesulfonic acid33 kDa chaperonintarget
2-(N-morpholino)ethanesulfonic acidFree methionine-R-sulfoxide reductasetarget
2-(N-morpholino)ethanesulfonic acidOrnithine cyclodeaminasetarget
2-(N-morpholino)ethanesulfonic acidDihydropteridine reductasetarget
2-(N-morpholino)ethanesulfonic acidArgininosuccinate lyasetarget
2-(N-morpholino)ethanesulfonic acidO-acetyl-ADP-ribose deacetylasetarget
2-(N-morpholino)ethanesulfonic acidADP-ribosylation factor-like protein 3target
2-(N-morpholino)ethanesulfonic acidBeta-lactamasetarget
2-(N-morpholino)ethanesulfonic acid3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsCtarget
2-(N-morpholino)ethanesulfonic acidLethal(3)malignant brain tumor-like protein 1target
2-(N-morpholino)ethanesulfonic acidCholinesterasetarget
2-(N-morpholino)ethanesulfonic acidRibonuclease Ztarget
2-(N-morpholino)ethanesulfonic acidPeroxiredoxin-6target
2-(N-morpholino)ethanesulfonic acidHypothetical gliding proteintarget
2-(N-morpholino)ethanesulfonic acidProlyl endopeptidase Peptarget
2-(N-morpholino)ethanesulfonic acidPulmonary surfactant-associated protein A1target
2-(N-morpholino)ethanesulfonic acidManganese catalasetarget
2-(N-morpholino)ethanesulfonic acidChorismate mutase AroHtarget
2-(N-morpholino)ethanesulfonic acidPutative cytochrome P450target
2-(N-morpholino)ethanesulfonic acidInterferon-inducible GTPase 5target
ViltolarsenDMD gene (exon 53 viltolarsen target site)target
CasimersenDMD gene (exon 45 casimersen target site)target
CasimersenCytochrome P450 3A4enzyme
CasimersenCytochrome P450 3A5enzyme
CasimersenCytochrome P450 2C9enzyme
CasimersenCytochrome P450 2C19enzyme