Cepharanthine

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DB16824InvestigationalSmall molecule

Cepharanthine: Overview.

Mechanism: Pharmacologically active on Phospholipase A2 and Nuclear factor NF-kappa-B
Curator reviewed
Formula / weight: C₃₇H₃₈N₂O₆ · 606.719 g/mol (avg)
Code names: BRN 0075231 · CCRIS 6539 · NSC-623442

Resolves to

Compound

UNII7592YJ0J6TCAS481-49-2ChEMBLCHEMBL449782ChEBI3546KEGGC09391

Structure

InChIKeyYVPXVXANRNDGTA-WDYNHAJCSA-NSMILES[H][C@@]12CC3=CC(OC4=CC=C(C[C@]5([H])N(C)CCC6=C5C(OC5=CC1=C(CCN2C)C=C5OC)=C1OCOC1=C6)C=C4)=C(OC)C=C3

Targets

P04054PLA2G1B

Transporters

P08183ABCB1Q5T3U5ABCC10

What you can answer from here — as of July 08, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2TransportersSubstrate / inhibitor direction, not just membership

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

13+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cepharanthine, and which of those have an active Phase 3 trial?

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