NADPH--cytochrome P450 reductase

BE0002364ProteinHumansPOR

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It is acted on by 22 drugs in DrugBank.

Gene name
POR
UniProtKB entry
P16435Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
677 residues · 76,689 Da
Also known as
1.6.2.4 · CPR · CYPOR · P450R

Resolves to

Protein
UniProtP16435UniProt nameNCPR_HUMAN
Gene
HGNCHGNC:9208NCBI Gene5447GenBank247307GeneCardsPOR
Pharmacology
KEGGhsa:5447
Structure
PDB1B1CPDB3FJOPDB3QE2
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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50+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADPH--cytochrome P450 reductase, how selective are they, and which programs against it are still in active trials?

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