Vascular endothelial growth factor receptor 2

BE0000369ProteinHumansKDR

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. It is acted on by 89 drugs in DrugBank.

Gene name
KDR
UniProtKB entry
P35968Swiss-Prot
Cellular location
Cell junction
Residues / weight
1,356 residues · 151,526 Da
Also known as
2.7.10.1 · Fetal liver kinase 1 · FLK-1 · FLK1 · KDR

Resolves to

Protein
UniProtP35968UniProt nameVGFR2_HUMAN
Gene
HGNCHGNC:6307NCBI Gene3791GenBank2655412GeneCardsKDR
Pharmacology
IUPHAR/GtoPdb1813KEGGhsa:3791
Structure
PDB1VR2PDB1Y6APDB1Y6B
Drugs

What you can answer from here — as of September 07, 2019

89DrugsApproved to experimental, with action, bond type and pharmacological action
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147Clinical trialsTrials of drugs acting on it, by phase and status
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40GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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337+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vascular endothelial growth factor receptor 2, how selective are they, and which programs against it are still in active trials?

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