Vascular endothelial growth factor receptor 1

BE0000029ProteinHumansFLT1

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis,... It is acted on by 35 drugs in DrugBank.

Gene name
FLT1
UniProtKB entry
P17948Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,338 residues · 150,767 Da
Also known as
2.7.10.1 · FLT · FLT-1 · Fms-like tyrosine kinase 1 · FRT

Resolves to

Protein
UniProtP17948UniProt nameVGFR1_HUMAN
Gene
HGNCHGNC:3763NCBI Gene2321GenBank31432GeneCardsFLT1
Pharmacology
IUPHAR/GtoPdb1812KEGGhsa:2321
Structure
PDB1FLTPDB1QSVPDB1QSZ
Drugs

What you can answer from here — as of September 07, 2019

35DrugsApproved to experimental, with action, bond type and pharmacological action
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63Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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128+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Vascular endothelial growth factor receptor 1, how selective are they, and which programs against it are still in active trials?

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