NAV

ABBV-CLS-7262

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
ABBV-CLS-7262
DrugBank Accession Number
DB18407
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 782.48
Monoisotopic: 781.1357666
Chemical Formula
C29H37Cl2F2N3NaO12P
Synonyms
  • Sodium ({(2S)-1,4-bis[2-(4-chloro-3- fluorophenoxy)acetamido]bicyclo[2.2.2]octan-2- yl}oxy)methyl hydrogen phosphate - 2-amino-2- (hydroxymethyl)propane-1,3-diol (1/1/1)
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
BN9FN5629V
CAS number
Not Available
InChI Key
RQOVFRFZOGXABE-IPMISBIPSA-M
InChI
InChI=1S/C25H27Cl2F2N2O9P.C4H11NO3.Na/c26-17-3-1-15(9-19(17)28)37-12-22(32)30-24-5-7-25(8-6-24,21(11-24)39-14-40-41(34,35)36)31-23(33)13-38-16-2-4-18(27)20(29)10-16;5-4(1-6,2-7)3-8;/h1-4,9-10,21H,5-8,11-14H2,(H,30,32)(H,31,33)(H2,34,35,36);6-8H,1-3,5H2;/q;;+1/p-1/t21-,24?,25?;;/m0../s1
IUPAC Name
sodium 2-amino-2-(hydroxymethyl)propane-1,3-diol {[(2S)-1,4-bis[2-(4-chloro-3-fluorophenoxy)acetamido]bicyclo[2.2.2]octan-2-yl]oxy}methyl hydrogen phosphate
SMILES
[Na+].NC(CO)(CO)CO.OP([O-])(=O)OCO[C@H]1CC2(CCC1(CC2)NC(=O)COC1=CC=C(Cl)C(F)=C1)NC(=O)COC1=CC=C(Cl)C(F)=C1

References

General References
Not Available
Wikipedia
Fosigotifator

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3Enrolling by InvitationTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2, 3RecruitingTreatmentAmyotrophic Lateral Sclerosis (ALS)1
1Active Not RecruitingTreatmentAmyotrophic Lateral Sclerosis (ALS)1
1CompletedTreatmentHealthy Volunteers (HV)2
1RecruitingBasic ScienceHealthy Volunteers (HV)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.89Chemaxon
pKa (Strongest Acidic)1.43Chemaxon
pKa (Strongest Basic)3.21Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count8Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area155.48 Å2Chemaxon
Rotatable Bond Count15Chemaxon
Refractivity139.36 m3·mol-1Chemaxon
Polarizability59.08 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at September 21, 2023 22:23 / Updated at February 05, 2024 00:29