APPD

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DB18603ExperimentalSmall molecule

APPD: Overview.

Mechanism: Pharmacologically active on Estrogen receptor, Androgen receptor, and Toll-like receptor 7
Curator reviewed
Formula / weight: C₃₉H₅₀F₃N₇O₁₃ · 881.86 g/mol (avg)
Also known as: AMINOURIDYL PHENOXYPIPERIDINBENZYL BUTAMIDE · D-GLYCERO-.ALPHA.-L-TALO-HEPTOFURANURONAMIDE, 5-O-(5-AMINO-5-DEOXY-.BETA.-D-RIBOFURANOSYL)-1,6-DIDEOXY-1-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-6-((4-OXO-4-(((4-(4-(4-(TRIFLUOROMETHOXY)PHENOXY)-1-PIPERIDINYL)PHENYL)METHYL)AMINO)BUTYL)AMINO)-
Code names: APPD

Resolves to

Compound

UNIIYG9BKQ6J2ZCAS2364414-26-4ChEMBLCHEMBL4776441

Structure

InChIKeyXXRKRPJUCVNNCH-AMFJOBICSA-NSMILES

[H][C@@]1(O[C@@H]([C@H](NCCCC(=O)NCC2=CC=C(C=C2)N2CCC(CC2)OC2=CC=C(OC(F)(F)F)C=C2)C(N)=O)[C@@]2([H])O[C@H]([C@H](O)[C@@H]2O)N2C=CC(=O)NC2=O)O[C@H](CN)[C@@H](O)[C@H]1O

Targets

P03372ESR1P10275AR Q9NYK1TLR7Q8IB24Heat shock 70 kDa protein

Transporters

P08183ABCB1

What you can answer from here — as of July 09, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with APPD, and which of those have an active Phase 3 trial?

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