JNJ-39758979

DB18899InvestigationalSmall molecule

JNJ-39758979 is under investigation in clinical trial NCT01480388 (A Dose Range Finding Study of JNJ-39758979 in Patients With Active Rheumatoid Arthritis Currently Treated With Methotrexate).

Mechanism: Pharmacologically active on Histamine H4 receptor
Curator reviewed
Formula / weight: C₁₁H₁₉N₅ · 221.308 g/mol (avg)
Also known as: 2-PYRIMIDINAMINE, 4-((3R)-3-AMINO-1-PYRROLIDINYL)-6-(1-METHYLETHYL)-
Code names: JNJ-39758979

Resolves to

Compound

UNII5RV7T5BNMGCAS1046447-90-8ChEMBLCHEMBL3236549

Structure

InChIKeyCOOGVHJHSCBOQT-MRVPVSSYSA-NSMILESCC(C)C1=CC(=NC(N)=N1)N1CC[C@@H](N)C1

Targets

Q9H3N8HRH4

What you can answer from here — as of July 09, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with JNJ-39758979, and which of those have an active Phase 3 trial?

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