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Danicamtiv

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Identification

Generic Name
Danicamtiv
DrugBank Accession Number
DB18962
Background

Danicamtiv is under investigation in clinical trial NCT04572893 (Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 435.42
Monoisotopic: 435.118809807
Chemical Formula
C16H20F3N5O4S
Synonyms
  • 1-piperidinecarboxamide, 4-((1r)-1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-n-3-isoxazolyl-
  • 4-((1r)-1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-n-(1,2-oxazol-3-yl)piperidine-1-carboxamide
External IDs
  • MYK-491
  • MYK491
  • SAR-440181
  • SAR440181
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7B2CS922HI
CAS number
1970972-74-7
InChI Key
NREKKBAMVWQRES-MRXNPFEDSA-N
InChI
InChI=1S/C16H20F3N5O4S/c1-16(19,29(26,27)11-9-23(2)21-13(11)14(17)18)10-3-6-24(7-4-10)15(25)20-12-5-8-28-22-12/h5,8-10,14H,3-4,6-7H2,1-2H3,(H,20,22,25)/t16-/m0/s1
IUPAC Name
SMILES
CN1C=C(C(=N1)C(F)F)S(=O)(=O)[C@@](C)(F)C1CCN(CC1)C(=O)NC1=NOC=C1

References

General References
Not Available
ChemSpider
81367782
ChEMBL
CHEMBL4594304
Wikipedia
Danicamtiv

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2TerminatedTreatmentPrimary Familial Dilated Cardiomyopathy1somestatusstop reasonjust information to hide
1CompletedTreatmentHealthy Volunteers (HV)3somestatusstop reasonjust information to hide
1CompletedTreatmentHearth Failure With Reduced Ejection Fraction (HFrEF)1somestatusstop reasonjust information to hide
1, 2CompletedTreatmentDilated Cardiomyopathy (DCM) / Hearth Failure With Reduced Ejection Fraction (HFrEF)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 27, 2024 16:42 / Updated at June 28, 2024 04:46