Tozasertib

DB19675InvestigationalSmall molecule

Tozasertib is a small molecule drug. The usage of the INN stem '-sertib' in the name indicates that Tozasertib is a serine/threonine kinase inhibitor. Tozasertib is under investigation in clinical... Tozasertib is under investigation in clinical trial NCT02532868 (A VX-680 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Cancer (0457-002)).

Chemical structure of Tozasertib
Formula / weight
C23H28N8OS · 464.59 g/mol (avg)
Code names
VX-680

Resolves to

Compound
UNII234335M86KCAS639089-54-6ChEMBLCHEMBL572878ChEBI91336PubChem5494449
Structure
InChIKeyGCIKSSRWRFVXBI-UHFFFAOYSA-NSMILESCN1CCN(CC1)C1=CC(NC2=NNC(C)=C2)=NC(SC2=CC=C(NC(=O)C3CC3)C=C2)=N1
Targets
O14965AURKAP06239LCKQ96GD4AURKB

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
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2Clinical trialsPhase, status and sponsor resolved per trial
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19+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Tozasertib, and which of those have an active Phase 3 trial?

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