Aurora kinase B

BE0003404ProteinHumansAURKB

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis (PubMed:11516652, PubMed:12925766, PubMed:14610074, PubMed:14722118, PubMed:29449677). It is acted on by 27 drugs in DrugBank.

Gene name
AURKB
UniProtKB entry
Q96GD4Swiss-Prot
Cellular location
Nucleus
Residues / weight
344 residues · 39,310 Da
Also known as
2.7.11.1 · AIK2 · AIM-1 · AIM1 · AIRK2

Resolves to

Protein
UniProtQ96GD4UniProt nameAURKB_HUMAN
Gene
HGNCHGNC:11390NCBI Gene9212GeneCardsAURKB
Pharmacology
IUPHAR/GtoPdb1937KEGGhsa:9212
Structure
PDB4AF3
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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120+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aurora kinase B, how selective are they, and which programs against it are still in active trials?

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