Aurora kinase A

BE0000991ProteinHumansAURKA

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). It is acted on by 32 drugs in DrugBank.

Gene name
AURKA
UniProtKB entry
O14965Swiss-Prot
Cellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Residues / weight
403 residues · 45,823 Da
Also known as
2.7.11.1 · AIK · AIRK1 · ARK-1 · ARK1

Resolves to

Protein
UniProtO14965UniProt nameAURKA_HUMAN
Gene
HGNCHGNC:11393NCBI Gene6790GenBank2641948GeneCardsAURKA
Pharmacology
IUPHAR/GtoPdb1936KEGGhsa:6790
Structure
PDB1MQ4PDB1MUOPDB1OL5
Drugs

What you can answer from here — as of September 07, 2019

32DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
14Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
20GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
151+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Aurora kinase A, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In