Tyrosine-protein kinase Lck

BE0000842ProteinHumansLCK

Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells (PubMed:2470098). It is acted on by 28 drugs in DrugBank.

Gene name
LCK
UniProtKB entry
P06239Swiss-Prot
Cellular location
Cell membrane
Residues / weight
509 residues · 58,000 Da
Also known as
2.7.10.2 · Leukocyte C-terminal Src kinase · LSK · Lymphocyte cell-specific protein-tyrosine kinase · p56-LCK

Resolves to

Protein
UniProtP06239UniProt nameLCK_HUMAN
Gene
HGNCHGNC:6524NCBI Gene3932GenBank36808GeneCardsLCK
Pharmacology
IUPHAR/GtoPdb2053KEGGhsa:3932
Structure
PDB1BHFPDB1BHHPDB1CWD
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
125+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Tyrosine-protein kinase Lck, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In