Utatrectinib

DB21295InvestigationalSmall molecule

Utatrectinib is a small molecule drug. The usage of the INN stem '-trectinib' in the name indicates that Utatrectinib is a tropomyosin receptor kinase (TRK) inhibitor. Utatrectinib is under investigation... Utatrectinib is under investigation in clinical trial NCT01468324 (AZD7451 for Recurrent Gliomas).

Mechanism: Pharmacologically active on High affinity nerve growth factor receptor, BDNF/NT-3 growth factors receptor, and NT-3 growth factor receptor
Curator reviewed
Formula / weight: C₁₈H₁₉FN₈O · 382.403 g/mol (avg)
Code names: AZD-7451

Resolves to

Compound

UNIIVNM956Y27VCAS1079274-94-4ChEMBLCHEMBL3659497ChEBI755686PubChem25115967

Structure

InChIKeyAYOOGWWGECJQPI-NSHDSACASA-NSMILESCC(C)OC1=CC(=NN1)N1C=NC2=CC=C(N[C@@H](C)C3=NC=C(F)C=N3)N=C12

Targets

P04629NTRK1Q16620NTRK2Q16288NTRK3

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Utatrectinib, and which of those have an active Phase 3 trial?

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