High affinity nerve growth factor receptor

BE0001039ProteinHumansNTRK1

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. It is acted on by 28 drugs in DrugBank.

Gene name
NTRK1
UniProtKB entry
P04629Swiss-Prot
Cellular location
Cell membrane
Residues / weight
796 residues · 87,496 Da
Also known as
2.7.10.1 · gp140trk · MTC · Neurotrophic tyrosine kinase receptor type 1 · p140-TrkA

Resolves to

Protein
UniProtP04629UniProt nameNTRK1_HUMAN
Gene
HGNCHGNC:8031NCBI Gene4914GenBank339918GeneCardsNTRK1
Pharmacology
IUPHAR/GtoPdb1817KEGGhsa:4914
Structure
PDB1HE7PDB1SHCPDB1WWA
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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103+ReferencesStructured and connected to the statements they support
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Which approved drugs act on High affinity nerve growth factor receptor, how selective are they, and which programs against it are still in active trials?

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