BDNF/NT-3 growth factors receptor

BE0003605ProteinHumansNTRK2

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). It is acted on by 20 drugs in DrugBank.

Gene name
NTRK2
UniProtKB entry
Q16620Swiss-Prot
Cellular location
Cell membrane
Residues / weight
822 residues · 91,998 Da
Also known as
2.7.10.1 · GP145-TrkB · Neurotrophic tyrosine kinase receptor type 2 · Trk-B · TRKB

Resolves to

Protein
UniProtQ16620UniProt nameNTRK2_HUMAN
Gene
HGNCHGNC:8032NCBI Gene4915GenBank530791GeneCardsNTRK2
Pharmacology
IUPHAR/GtoPdb1818KEGGhsa:4915
Structure
PDB1HCFPDB1WWBPDB2MFQ
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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27GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on BDNF/NT-3 growth factors receptor, how selective are they, and which programs against it are still in active trials?

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