Zurletrectinib

DB21601ExperimentalSmall molecule

Zurletrectinib is a small molecule drug. The usage of the INN stem '-trectinib' in the name indicates that Zurletrectinib is a tropomyosin receptor kinase (TRK) inhibitor. Zurletrectinib has a monoisotopic...

Mechanism: Pharmacologically active on High affinity nerve growth factor receptor, BDNF/NT-3 growth factors receptor, and NT-3 growth factor receptor
Curator reviewed
Formula / weight: C₁₉H₁₉F₂N₇O₂ · 415.405 g/mol (avg)

Resolves to

Compound

UNIIZVQ44E2H6VCAS2403703-30-8ChEMBLCHEMBL5095426ChEBI758988PubChem156371488

Structure

InChIKeyOIBWCYRRWAMTRW-ITDIGPHOSA-NSMILES[H][C@]12C[C@H](F)CN1C1=NC3=C(NC(=O)NC[C@H](C)OC4=C2C=C(F)C=N4)C=NN3C=C1

Targets

P04629NTRK1Q16620NTRK2Q16288NTRK3

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Zurletrectinib, and which of those have an active Phase 3 trial?

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