Propranolol hydrochlorideProduct ingredient for Propranolol
- Name
- Propranolol hydrochloride
- Drug Entry
- Propranolol
Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.9 Propranolol is used to treat a number of conditions but most commonly is used for hypertension.8,9,10
Propranolol was granted FDA approval on 13 November 1967.9
- Accession Number
- DBSALT000549
- Structure
- Synonyms
- Propranolol HCl
- UNII
- F8A3652H1V
- CAS Number
- 318-98-9
- Weight
- Average: 295.804
Monoisotopic: 295.13390666 - Chemical Formula
- C16H22ClNO2
- InChI Key
- ZMRUPTIKESYGQW-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
- IUPAC Name
- 1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol hydrochloride
- SMILES
- Cl.CC(C)NCC(O)COC1=CC=CC2=CC=CC=C12
- External Links
- PubChem Compound
- 62882
- ChemSpider
- 56610
- ChEBI
- 8500
- ChEMBL
- CHEMBL1671
- Wikipedia
- Propranolol
- Predicted Properties
Property Value Source Water Solubility 0.0794 mg/mL ALOGPS logP 3.03 ALOGPS logP 2.58 Chemaxon logS -3.5 ALOGPS pKa (Strongest Acidic) 14.09 Chemaxon pKa (Strongest Basic) 9.67 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 41.49 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 76.83 m3·mol-1 Chemaxon Polarizability 29.84 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon