Oxymetazoline hydrochlorideProduct ingredient for Oxymetazoline
- Name
- Oxymetazoline hydrochloride
- Drug Entry
- Oxymetazoline
Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2-adrenoceptors.1 Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults.17 As an effective decongestant, oxymetazoline is available in over-the-counter intranasal sprays used to relieve nasal and sinus congestion caused by a wide variety of conditions, such as common cold, hay fever, and upper respiratory allergies.3,20 In dentistry, oxymetazoline and tetracaine combination intranasal spray (Kovanaze) is used for regional anesthesia during dental procedures in children and adults.16 In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline (Upneeq) in adults with acquired blepharoptosis, or ptosis, making it the first FDA-approved medical treatment for this medical condition.15,18
- Accession Number
- DBSALT000821
- Structure
Structure for Oxymetazoline hydrochloride (DBSALT000821)
- Synonyms
- Oxymetazoline HCl / Oxymetazoline hydrochloride
- External IDs
- SCH 9384
- UNII
- K89MJ0S5VY
- CAS Number
- 2315-02-8
- Weight
- Average: 296.836
Monoisotopic: 296.165541139 - Chemical Formula
- C16H25ClN2O
- InChI Key
- BEEDODBODQVSIM-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H24N2O.ClH/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14;/h8,19H,6-7,9H2,1-5H3,(H,17,18);1H
- IUPAC Name
- 6-tert-butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,4-dimethylphenol hydrochloride
- SMILES
- Cl.CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C
- External Links
- PubChem Compound
- 66259
- ChemSpider
- 59640
- ChEBI
- 7863
- ChEMBL
- CHEMBL1200791
- Wikipedia
- Oxymetazoline
- Predicted Properties
Property Value Source Water Solubility 0.0515 mg/mL ALOGPS logP 3.7 ALOGPS logP 3.03 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 10.91 Chemaxon pKa (Strongest Basic) 10.15 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 44.62 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 79.8 m3·mol-1 Chemaxon Polarizability 30.62 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon