Paliperidone palmitateProduct ingredient for Paliperidone
- Name
- Paliperidone palmitate
- Drug Entry
- Paliperidone
Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006. It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.3,5,4,6
- Accession Number
- DBSALT001464
- Structure
- Synonyms
- Not Available
- UNII
- R8P8USM8FR
- CAS Number
- 199739-10-1
- Weight
- Average: 664.907
Monoisotopic: 664.436384494 - Chemical Formula
- C39H57FN4O4
- InChI Key
- VOMKSBFLAZZBOW-UHFFFAOYSA-N
- InChI
- InChI=1S/C39H57FN4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36(45)47-34-17-16-24-44-38(34)41-29(2)32(39(44)46)23-27-43-25-21-30(22-26-43)37-33-20-19-31(40)28-35(33)48-42-37/h19-20,28,30,34H,3-18,21-27H2,1-2H3
- IUPAC Name
- 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-9-yl hexadecanoate
- SMILES
- CCCCCCCCCCCCCCCC(=O)OC1CCCN2C(=O)C(CCN3CCC(CC3)C3=NOC4=CC(F)=CC=C34)=C(C)N=C12
- External Links
- Human Metabolome Database
- HMDB0256085
- ChemSpider
- 8028457
- ChEBI
- 83808
- ChEMBL
- CHEMBL2107360
- Wikipedia
- Paliperidone
- Predicted Properties
Property Value Source Water Solubility 0.00704 mg/mL ALOGPS logP 8.12 ALOGPS logP 8.68 Chemaxon logS -5 ALOGPS pKa (Strongest Basic) 8.76 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 88.24 Å2 Chemaxon Rotatable Bond Count 20 Chemaxon Refractivity 189.63 m3·mol-1 Chemaxon Polarizability 80.13 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon