Paliperidone is an atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Paliperidone is the primary active metabolite of risperidone.
- Mechanism
- Curator reviewed
Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia, is unknown, but it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.
- Primary indication
- As an oral extended-release tablet and a once-monthly extended-release suspension for intramuscular injection, paliperidone is indicated for the treatment of adults and adolescents with schizophrenia and in the treatment of schizoaffective disorder in combination with...Curator reviewed · 9 structured indications
- Formula / weight
- C23H27FN4O3 · 426.4839 g/mol (avg)
- First approval
- Canada, 2007 · United States, 2006 · European Union, 2016
- Also known as
- 9-hydroxyrisperidone
- Code names
- R-76477 · RO-76477
- Brand names
Resolves to
PMXMIIMHBWHSKN-UHFFFAOYSA-NSMILESCC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCC(O)C2=N1What you can answer from here — as of September 30, 2026
Which drugs share a target with Paliperidone, and which of those have an active Phase 3 trial?
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