Heavy Menstrual Bleeding

Also known as: Bleeding menstrual heavy / Menorrhagia / Heavy menstrual period (finding) / Menorrhagia (finding) / Hypermenorrhea -RETIRED- / Heavy periods NOS / Hypermenorrhea / Excessive &/or frequent menstruation / Menstrual flow excessive / Hypermenorrhoea / Heavy periods / Excessive menstruation / Menses regular with excessive bleeding / Heavy menstrual period / Prolonged heavy periods / Menstruation increased

DrugDrug NameDrug Description
DB11979ElagolixA gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.
DB13956Estradiol valerateAn estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.
DB11853RelugolixAn oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer.
DB00302Tranexamic acidAn antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.
DrugDrug NameTargetType
DB11979ElagolixGonadotropin-releasing hormone receptortarget
DB11979ElagolixCytochrome P450 3A Subfamilyenzyme
DB11979ElagolixCytochrome P450 2D6enzyme
DB11979ElagolixCytochrome P450 2C8enzyme
DB11979ElagolixP-glycoprotein 1transporter
DB11979ElagolixSolute carrier organic anion transporter family member 1B1transporter
DB13956Estradiol valerateEstrogen receptor alphatarget
DB13956Estradiol valerateNuclear receptor subfamily 1 group I member 2target
DB13956Estradiol valerateSex hormone-binding globulincarrier
DB13956Estradiol valerateEstrogen receptor betatarget
DB13956Estradiol valerateCytochrome P450 1A2enzyme
DB13956Estradiol valerateUDP-glucuronosyltransferase 1-1enzyme
DB13956Estradiol valerateSerum albumincarrier
DB13956Estradiol valerateFatty acid-binding protein, intestinalcarrier
DB13956Estradiol valerateCytochrome P450 3A4enzyme
DB13956Estradiol valerateCytochrome P450 3A5enzyme
DB13956Estradiol valerateCytochrome P450 3A7enzyme
DB13956Estradiol valerateSolute carrier family 22 member 2transporter
DB13956Estradiol valerateSolute carrier family 22 member 1transporter
DB13956Estradiol valerateSolute carrier family 22 member 3transporter
DB13956Estradiol valerateSolute carrier organic anion transporter family member 2B1transporter
DB13956Estradiol valerateSolute carrier organic anion transporter family member 1A2transporter
DB13956Estradiol valerateMultidrug resistance-associated protein 7transporter
DB13956Estradiol valerateSolute carrier family 22 member 11transporter
DB13956Estradiol valerateATP-binding cassette sub-family G member 2transporter
DB13956Estradiol valerateSolute carrier organic anion transporter family member 1B1transporter
DB13956Estradiol valerateP-glycoprotein 1transporter
DB13956Estradiol valerateCytochrome P450 1A1enzyme
DB13956Estradiol valerateCytochrome P450 1B1enzyme
DB13956Estradiol valerateCytochrome P450 2C19enzyme
DB13956Estradiol valerateCytochrome P450 2C8enzyme
DB13956Estradiol valerateCytochrome P450 2C9enzyme
DB13956Estradiol valerateSolute carrier family 22 member 8transporter
DB13956Estradiol valerateSolute carrier organic anion transporter family member 1B3transporter
DB13956Estradiol valerateSolute carrier organic anion transporter family member 1C1transporter
DB13956Estradiol valerateSolute carrier organic anion transporter family member 4A1transporter
DB13956Estradiol valerateNeuronal acetylcholine receptor subunit alpha-4target
DB13956Estradiol valerateNuclear receptor coactivator 2target
DB13956Estradiol valerateG-protein coupled estrogen receptor 1target
DB13956Estradiol valerateATP synthase subunit atarget
DB13956Estradiol valerateBeclin-1target
DB13956Estradiol valerateEstradiol 17-beta-dehydrogenase 2target
DB13956Estradiol valerateEstrogen-related receptor gammatarget
DB11853RelugolixSerum albumincarrier
DB11853RelugolixAlpha-1-acid glycoprotein 1carrier
DB11853RelugolixP-glycoprotein 1transporter
DB11853RelugolixATP-binding cassette sub-family G member 2transporter
DB11853RelugolixCytochrome P450 3A Subfamilyenzyme
DB11853RelugolixCytochrome P450 2C8enzyme
DB11853RelugolixCytochrome P450 2B6enzyme
DB11853RelugolixGonadotropin-releasing hormone receptortarget
DB00302Tranexamic acidPlasminogentarget
DrugDrug NamePhaseStatusCount
DB00302Tranexamic acid1Withdrawn1
DB08867Ulipristal1Withdrawn1
DB01234Dexamethasone2Completed1
DB11979Elagolix3Active Not Recruiting1
DB11979Elagolix3Completed3
DB00783Estradiol3Active Not Recruiting1
DB00783Estradiol3Completed6
DB00367Levonorgestrel3Completed1
DB00603Medroxyprogesterone acetate3Completed1
DB00784Mefenamic acid3Completed1
DB00717Norethisterone3Active Not Recruiting1
DB00717Norethisterone3Completed6
DB11853Relugolix3Completed3
DB00302Tranexamic acid3Completed3
DB04928XP12B3Completed3
DB13257Ferrous sulfate anhydrous4Not Yet Recruiting1
DB13257Ferrous sulfate anhydrous4Recruiting1
DB06215Ferumoxytol4Not Yet Recruiting1
DB01592Iron4Not Yet Recruiting1
DB00893Iron Dextran4Recruiting1
DB00367Levonorgestrel4Completed1
DB00717Norethisterone4Unknown Status1
DB00302Tranexamic acid4Completed2
DB08867Ulipristal4Terminated1
DB08867Ulipristal4Unknown Status1
DB00802AlfentanilNot AvailableCompleted1
DB00479AmikacinNot AvailableCompleted1
DB00513Aminocaproic acidNot AvailableCompleted1
DB06605ApixabanNot AvailableNot Yet Recruiting1
DB00559BosentanNot AvailableCompleted1
DB01413CefepimeNot AvailableCompleted1
DB00369CidofovirNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableCompleted1
DB00363ClozapineNot AvailableCompleted1
DB14726DabigatranNot AvailableNot Yet Recruiting1
DB09075EdoxabanNot AvailableNot Yet Recruiting1
DB11979ElagolixNot AvailableRecruiting1
DB00783EstradiolNot AvailableRecruiting1
DB00828FosfomycinNot AvailableCompleted1
DB00502HaloperidolNot AvailableCompleted1
DB00598LabetalolNot AvailableCompleted1
DB00367LevonorgestrelNot AvailableCompleted1
DB08815LurasidoneNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableCompleted1
DB01618MolindoneNot AvailableCompleted1
DB00607NafcillinNot AvailableCompleted1
DB01115NifedipineNot AvailableCompleted1
DB00717NorethisteroneNot AvailableRecruiting1
DB00497OxycodoneNot AvailableCompleted1
DB00312PentobarbitalNot AvailableCompleted1
DB00319PiperacillinNot AvailableCompleted1
DB06228RivaroxabanNot AvailableNot Yet Recruiting1
DB00728RocuroniumNot AvailableCompleted1
DB00658SevelamerNot AvailableCompleted1
DB00421SpironolactoneNot AvailableCompleted1
DB01606TazobactamNot AvailableCompleted1
DB00684TobramycinNot AvailableCompleted1
DB00302Tranexamic acidNot AvailableCompleted1
DB00512VancomycinNot AvailableCompleted1
DB01339VecuroniumNot AvailableCompleted1
DB00682WarfarinNot AvailableCompleted1
DB00246ZiprasidoneNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted1