Norgestimate is a progesterone used as a contraceptive and to treat acne vulgaris. Norgestimate was first described in the literature in 1977.
- Mechanism
- Curator reviewed · 6 references
Progesterone analogs like norgestimate decrease the frequency of gonadotropin releasing hormone pulses from the hypothalamus, decreasing follicle stimulating hormone and luteinizing hormone. These actions prevent ovulation.
Norgestimate suppresses the hypothalamo-pituitary-axis, reducing androgen synthesis. It also induces production of sex hormone binding globulin, which decreases free testosterone. These actions together result in less testosterone being available to stimulate sebaceous glands, resulting in effective treatment of some forms of acne.
- Primary indication
- Norgestimate is formulated with ethinylestradiol as a combined oral contraceptive.Curator reviewed · 10 structured indications
- Formula / weight
- C23H31NO3 · 369.4971 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1989
- Also known as
- Dexnorgestrel Acetime
- Code names
- ORF 10131 · RWJ 10131
- Brand names
Resolves to
KIQQMECNKUGGKA-NMYWJIRASA-NSMILES[H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(CC)CC[C@]1([H])[C@@]3([H])CC\C(C=C3CC[C@@]21[H])=N/OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Norgestimate, and which of those have an active Phase 3 trial?
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