Metastatic Non-Small Cell Lung Cancer

Also known as: Metastatic NSCLC / Metastatic Non-Small Cell Lung Carcinoma / Metastatic Non-small Cell Lung Cancer (NSCLC) / Metastatic Non Small Cell Lung Cancer / Metastatic Non-Small-Cell Lung Cancer / Non-small cell lung cancer metastatic / Metastatic non-small cell lung cancer (disorder) / Lung cancer non-small cell stage IV / Non-small cell lung cancer stage IV

DrugDrug NameDrug Description
DB08916AfatinibAn antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
DB16695AmivantamabAn EGF and MET receptor targeted antibody indicated in the treatment of non-small cell lung cancer with an EGFR 20 exon insertion mutation.
DB11595AtezolizumabA monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
DB12267BrigatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
DB11791CapmatinibA kinase inhibitor targeting c-Met receptor tyrosine kinase in the treatment of non-small cell lung cancer with MET exon 14 skipping.
DB08865CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
DB11963DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
DB00530ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
DB00317GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
DB09559NecitumumabA monoclonal antibody used to treat metastatic squamous non-small cell lung cancer.
DB09035NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
DB09330OsimertinibA tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
DB01229PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DB15569SotorasibAn experimental KRAS inhibitor being investigated for the treatment of KRAS G12C mutant non small cell lung cancer, colorectal cancer, and appendix cancer.
DB15133TepotinibAn oral tyrosine kinase inhibitor targeted against MET for the treatment of metastatic non-small cell lung cancer in patients exhibiting MET exon 14 skipping mutations.
DrugDrug NameTargetType
DB08916AfatinibEpidermal growth factor receptortarget
DB08916AfatinibReceptor tyrosine-protein kinase erbB-2target
DB08916AfatinibReceptor tyrosine-protein kinase erbB-4target
DB08916AfatinibP-glycoprotein 1transporter
DB08916AfatinibATP-binding cassette sub-family G member 2transporter
DB16695AmivantamabEpidermal growth factor receptortarget
DB16695AmivantamabHepatocyte growth factor receptortarget
DB16695AmivantamabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB11595AtezolizumabProgrammed cell death 1 ligand 1target
DB12267BrigatinibALK tyrosine kinase receptortarget
DB12267BrigatinibEpidermal growth factor receptortarget
DB12267BrigatinibTyrosine-protein kinase ABL1target
DB12267BrigatinibInsulin-like growth factor 1 receptortarget
DB12267BrigatinibReceptor-type tyrosine-protein kinase FLT3target
DB12267BrigatinibCytochrome P450 2C8enzyme
DB12267BrigatinibCytochrome P450 3A4enzyme
DB12267BrigatinibInsulin receptortarget
DB12267BrigatinibHepatocyte growth factor receptortarget
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-4target
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-2target
DB12267BrigatinibATP-binding cassette sub-family B member 5transporter
DB12267BrigatinibATP-binding cassette sub-family G member 2transporter
DB12267BrigatinibSolute carrier family 22 member 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 2transporter
DB12267BrigatinibCytochrome P450 3A Subfamilyenzyme
DB11791CapmatinibCytochrome P450 3A4enzyme
DB11791CapmatinibAldehyde oxidaseenzyme
DB11791CapmatinibHepatocyte growth factor receptortarget
DB11791CapmatinibP-glycoprotein 1transporter
DB11791CapmatinibMultidrug and toxin extrusion protein 1transporter
DB11791CapmatinibMultidrug and toxin extrusion protein 2transporter
DB11791CapmatinibCytochrome P450 1A2enzyme
DB11791CapmatinibATP-binding cassette sub-family G member 2transporter
DB08865CrizotinibCytochrome P450 3A4enzyme
DB08865CrizotinibCytochrome P450 3A5enzyme
DB08865CrizotinibP-glycoprotein 1transporter
DB08865CrizotinibALK tyrosine kinase receptortarget
DB08865CrizotinibHepatocyte growth factor receptortarget
DB08865CrizotinibCytochrome P450 2B6enzyme
DB08865CrizotinibCytochrome P450 3A Subfamilyenzyme
DB11963DacomitinibCytochrome P450 2D6enzyme
DB11963DacomitinibSerum albumincarrier
DB11963DacomitinibCytochrome P450 3A4enzyme
DB11963DacomitinibCytochrome P450 2C9enzyme
DB11963DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DB11963DacomitinibP-glycoprotein 1transporter
DB11963DacomitinibATP-binding cassette sub-family G member 2transporter
DB11963DacomitinibSolute carrier family 22 member 1transporter
DB11963DacomitinibEpidermal growth factor receptortarget
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibP-glycoprotein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00530ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DB00317GefitinibEpidermal growth factor receptortarget
DB00317GefitinibCytochrome P450 3A4enzyme
DB00317GefitinibCytochrome P450 2D6enzyme
DB00317GefitinibP-glycoprotein 1transporter
DB00317GefitinibATP-binding cassette sub-family G member 2transporter
DB00317GefitinibCytochrome P450 3A5enzyme
DB00317GefitinibCytochrome P450 1A1enzyme
DB00317GefitinibCytochrome P450 2C9enzyme
DB00317GefitinibCytochrome P450 2C19enzyme
DB00317GefitinibSerum albumincarrier
DB00317GefitinibAlpha-1-acid glycoprotein 1carrier
DB09559NecitumumabEpidermal growth factor receptortarget
DB09035NivolumabProgrammed cell death protein 1target
DB09330OsimertinibEpidermal growth factor receptortarget
DB09330OsimertinibP-glycoprotein 1transporter
DB09330OsimertinibATP-binding cassette sub-family G member 2transporter
DB09330OsimertinibCytochrome P450 3A4enzyme
DB09330OsimertinibCytochrome P450 1A2enzyme
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelP-glycoprotein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB15569SotorasibGTPase KRastarget
DB15569SotorasibCytochrome P450 3A Subfamilyenzyme
DB15569SotorasibCytochrome P450 2C8enzyme
DB15569SotorasibCytochrome P450 2C9enzyme
DB15569SotorasibCytochrome P450 2B6enzyme
DB15569SotorasibATP-binding cassette sub-family G member 2transporter
DB15569SotorasibP-glycoprotein 1transporter
DB15133TepotinibP-glycoprotein 1transporter
DB15133TepotinibCytochrome P450 3A4enzyme
DB15133TepotinibCytochrome P450 2C8enzyme
DB15133TepotinibATP-binding cassette sub-family G member 2transporter
DB15133TepotinibHepatocyte growth factor receptortarget
DB15133TepotinibNischarintarget
DB15133TepotinibMelatonin receptor type 1Btarget
DB15133TepotinibSerum albumincarrier
DB15133TepotinibAlpha-1-acid glycoprotein 1carrier
DrugDrug NamePhaseStatusCount
DB00041Aldesleukin0Completed1
DB11945Avelumab0Recruiting1
DB09035Nivolumab0Completed1
DB09037Pembrolizumab0Completed1
DB12001Abemaciclib1Active Not Recruiting1
DB15327Abivertinib1Active Not Recruiting1
DB00041Aldesleukin1Active Not Recruiting1
DB11794Berzosertib1Recruiting1
DB00112Bevacizumab1Active Not Recruiting1
DB00112Bevacizumab1Recruiting2
DB12267Brigatinib1Recruiting1
DB08875Cabozantinib1Recruiting1
DB01373Calcium1Recruiting1
DB04690Camptothecin1Recruiting1
DB01101Capecitabine1Recruiting1
DB00958Carboplatin1Active Not Recruiting2
DB00958Carboplatin1Recruiting3
DB09063Ceritinib1Recruiting1
DB00002Cetuximab1Active Not Recruiting1
DB00515Cisplatin1Active Not Recruiting1
DB16372Cobolimab1Active Not Recruiting1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Completed1
DB00531Cyclophosphamide1Recruiting1
DB11963Dacomitinib1Active Not Recruiting1
DB14825Danvatirsen1Active Not Recruiting1
DB00694Daunorubicin1Recruiting1
DB01248Docetaxel1Recruiting1
DB15627Dostarlimab1Active Not Recruiting1
DB00997Doxorubicin1Recruiting1
DB11714Durvalumab1Active Not Recruiting1
DB11718Encorafenib1Active Not Recruiting1
DB14860Ensartinib1Recruiting2
DB08871Eribulin1Recruiting1
DB01073Fludarabine1Active Not Recruiting1
DB00544Fluorouracil1Recruiting1
DB11679Fruquintinib1Recruiting1
DB00441Gemcitabine1Active Not Recruiting3
DB16417Geptanolimab1Recruiting1
DB06186Ipilimumab1Recruiting1
DB00762Irinotecan1Recruiting1
DB00650Leucovorin1Recruiting1
DB11596Levoleucovorin1Recruiting1
DB05477MUC1 Dendritic Cell Vaccine1Active Not Recruiting1
DB00683Midazolam1Active Not Recruiting1
DB09559Necitumumab1Active Not Recruiting1
DB11793Niraparib1Active Not Recruiting1
DB09035Nivolumab1Active Not Recruiting1
DB09035Nivolumab1Recruiting3
DB09074Olaparib1Recruiting1
DB15088Oleclumab1Active Not Recruiting1
DB09330Osimertinib1Active Not Recruiting3
DB09330Osimertinib1Not Yet Recruiting1
DB09330Osimertinib1Recruiting2
DB00526Oxaliplatin1Recruiting1
DB01229Paclitaxel1Active Not Recruiting4
DB01229Paclitaxel1Recruiting1
DB06589Pazopanib1Terminated1
DB09037Pembrolizumab1Active Not Recruiting2
DB09037Pembrolizumab1Recruiting4
DB00642Pemetrexed1Active Not Recruiting2
DB00642Pemetrexed1Recruiting3
DB05992Plinabulin1Recruiting1
DB11836Sapanisertib1Active Not Recruiting1
DB11836Sapanisertib1Recruiting1
DB11942Selinexor1Recruiting1
DB09143Sonidegib1Recruiting1
DB15232Telaglenastat1Recruiting2
DB01030Topotecan1Recruiting1
DB00135Tyrosine1Recruiting1
DB00361Vinorelbine1Terminated1
DB13104X-3961Recruiting2
DB05220Alisertib1 / 2Terminated1
DB11595Atezolizumab1 / 2Recruiting2
DB11945Avelumab1 / 2Active Not Recruiting1
DB06626Axitinib1 / 2Active Not Recruiting1
DB11105Benzalkonium1 / 2Completed1
DB15387Bintrafusp alfa1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting2
DB11714Durvalumab1 / 2Active Not Recruiting1
DB00530Erlotinib1 / 2Terminated1
DB01073Fludarabine1 / 2Recruiting2
DB06186Ipilimumab1 / 2Recruiting2
DB09559Necitumumab1 / 2Recruiting1
DB14145Nepidermin1 / 2Recruiting1
DB09079Nintedanib1 / 2Recruiting1
DB09035Nivolumab1 / 2Completed1
DB06132Nivolumab1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting3
DB09330Osimertinib1 / 2Not Yet Recruiting1
DB09330Osimertinib1 / 2Recruiting1
DB09073Palbociclib1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Active Not Recruiting2
DB09037Pembrolizumab1 / 2Recruiting1
DB14904Pimasertib1 / 2Recruiting1
DB16413Sotigalimab1 / 2Completed1
DB08911Trametinib1 / 2Active Not Recruiting1
DB00072Trastuzumab1 / 2Recruiting1
DB11771Tremelimumab1 / 2Active Not Recruiting1
DB15310Vactosertib1 / 2Active Not Recruiting1
DB15327Abivertinib2Recruiting1
DB00062Albumin human2Not Yet Recruiting2
DB11363Alectinib2Terminated1
DB16640Almonertinib2Active Not Recruiting1
DB11885Anlotinib2Not Yet Recruiting1
DB11595Atezolizumab2Not Yet Recruiting1
DB11595Atezolizumab2Recruiting1
DB00112Bevacizumab2Active Not Recruiting2
DB00112Bevacizumab2Completed1
DB00112Bevacizumab2Not Yet Recruiting1
DB00112Bevacizumab2Unknown Status1
DB06772Cabazitaxel2Completed1
DB12218Capivasertib2Active Not Recruiting1
DB00958Carboplatin2Completed1
DB00958Carboplatin2Not Yet Recruiting2
DB00958Carboplatin2Recruiting5
DB04849Cediranib2Recruiting1
DB00515Cisplatin2Active Not Recruiting1
DB00515Cisplatin2Completed1
DB00515Cisplatin2Not Yet Recruiting1
DB00515Cisplatin2Recruiting1
DB00515Cisplatin2Suspended1
DB00515Cisplatin2Terminated1
DB05239Cobimetinib2Recruiting1
DB01914D-glucose2Recruiting1
DB11963Dacomitinib2Recruiting1
DB01248Docetaxel2Active Not Recruiting1
DB01248Docetaxel2Completed2
DB01248Docetaxel2Not Yet Recruiting1
DB01248Docetaxel2Recruiting4
DB01248Docetaxel2Suspended1
DB11714Durvalumab2Active Not Recruiting2
DB11714Durvalumab2Recruiting1
DB00530Erlotinib2Completed2
DB14951Etirinotecan pegol2Completed1
DB00544Fluorouracil2Completed1
DB00441Gemcitabine2Completed2
DB00441Gemcitabine2Terminated1
DB00762Irinotecan2Completed1
DB01167Itraconazole2Terminated1
DB12167LY-30234142Terminated1
DB00825Levomenthol2Completed1
DB06599Lexatumumab2Recruiting2
DB12130Lorlatinib2Not Yet Recruiting1
DB12130Lorlatinib2Recruiting1
DB00331Metformin2Terminated1
DB05774Necitumumab2Terminated1
DB09559Necitumumab2Terminated1
DB06192Nimotuzumab2Terminated1
DB09035Nivolumab2Active Not Recruiting3
DB09035Nivolumab2Not Yet Recruiting1
DB09035Nivolumab2Recruiting3
DB09035Nivolumab2Withdrawn1
DB09074Olaparib2Active Not Recruiting1
DB09074Olaparib2Recruiting1
DB09330Osimertinib2Active Not Recruiting2
DB09330Osimertinib2Recruiting3
DB01229Paclitaxel2Active Not Recruiting1
DB01229Paclitaxel2Completed1
DB01229Paclitaxel2Not Yet Recruiting2
DB01229Paclitaxel2Recruiting2
DB09037Pembrolizumab2Active Not Recruiting2
DB09037Pembrolizumab2Recruiting7
DB00642Pemetrexed2Active Not Recruiting2
DB00642Pemetrexed2Completed3
DB00642Pemetrexed2Not Yet Recruiting2
DB00642Pemetrexed2Recruiting6
DB06366Pertuzumab2Active Not Recruiting1
DB05578Ramucirumab2Completed1
DB05578Ramucirumab2Recruiting3
DB14851Relatlimab2Recruiting1
DB15766Retifanlimab2Active Not Recruiting1
DB12893Sacituzumab govitecan2Recruiting1
DB12183Sapitinib2Active Not Recruiting1
DB12048Savolitinib2Active Not Recruiting1
DB11689Selumetinib2Active Not Recruiting1
DB15765Sintilimab2Not Yet Recruiting2
DB04900Thymalfasin2Withdrawn1
DB12200Tivantinib2Completed1
DB00072Trastuzumab2Active Not Recruiting1
DB11771Tremelimumab2Active Not Recruiting1
DB15442Trilaciclib2Recruiting1
DB00577Valaciclovir2Active Not Recruiting1
DB05294Vandetanib2Active Not Recruiting1
DB16420Vibostolimab2Recruiting1
DB00361Vinorelbine2Recruiting1
DB11925Vistusertib2Active Not Recruiting1
DB01248Docetaxel2 / 3Terminated1
DB12047Ganetespib2 / 3Terminated1
DB00853Temozolomide2 / 3Not Yet Recruiting1
DB11595Atezolizumab3Recruiting1
DB05136Bavituximab3Completed1
DB00112Bevacizumab3Completed1
DB00112Bevacizumab3Recruiting1
DB00112Bevacizumab3Terminated1
DB00112Bevacizumab3Withdrawn1
DB00958Carboplatin3Completed1
DB00958Carboplatin3Recruiting2
DB00958Carboplatin3Withdrawn1
DB00515Cisplatin3Active Not Recruiting2
DB00515Cisplatin3Recruiting1
DB00515Cisplatin3Terminated1
DB01248Docetaxel3Completed1
DB01248Docetaxel3Recruiting3
DB01248Docetaxel3Terminated1
DB00530Erlotinib3Active Not Recruiting1
DB12047Ganetespib3Terminated1
DB00317Gefitinib3Active Not Recruiting1
DB00441Gemcitabine3Active Not Recruiting2
DB06186Ipilimumab3Recruiting1
DB09078Lenvatinib3Recruiting1
DB15568MRTX8493Recruiting1
DB01043Memantine3Recruiting1
DB09035Nivolumab3Recruiting1
DB09330Osimertinib3Active Not Recruiting1
DB01229Paclitaxel3Completed1
DB01229Paclitaxel3Recruiting2
DB01229Paclitaxel3Withdrawn1
DB09037Pembrolizumab3Recruiting2
DB00642Pemetrexed3Active Not Recruiting1
DB00642Pemetrexed3Recruiting1
DB00642Pemetrexed3Terminated1
DB05578Ramucirumab3Active Not Recruiting1
DB00958Carboplatin4Terminated1
DB11963Dacomitinib4Recruiting1
DB00530Erlotinib4Suspended1
DB00317Gefitinib4Terminated1
DB00441Gemcitabine4Not Yet Recruiting1
DB00441Gemcitabine4Terminated1
DB09035Nivolumab4Not Yet Recruiting1
DB09037Pembrolizumab4Recruiting1
DB00361Vinorelbine4Completed1
DB16695AmivantamabNot AvailableAvailable1
DB09037PembrolizumabNot AvailableRecruiting1
DB00135TyrosineNot AvailableUnknown Status1