Type One Diabetes Completed Phase 1 Trials for Insulin lispro (DB00046)

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Also known as: Diabetes Mellitus, Juvenile-Onset / T1DM - Type 1 Diabetes Mellitus / Diabetes Type I / Type I Diabetes / Type1 Diabetes / Diabetes Type One / Diabete Type 1 / Type One Diabetes Mellitus / Diabetics Mellitus Type 1 / Type 1 Diabetes / Type 1 Diabetes Mellitus (T1DM) / Insulin-Dependent Diabetes Mellitus 1 / Type1diabetes / Diabetes Mellitus Type I / Type1 Diabetes Mellitus / Type 1 Diabetes (T1D) / Diabetes Mellitus Type 1 / Juvenile Onset Diabetes Mellitus / Diabetes Type 1 / Type 1 Insulin-Dependent Diabetes Mellitus / Type I Diabetes Mellitus / Diabetes Mellitus, Sudden-Onset / Type-1 Diabetes Mellitus / Insulin Dependent Diabetes Mellitus 1 / Type 1 Diabetes Mellitus / Juvenile-Onset Diabetes / Diabetes Mellitus, Insulin-Dependent, 1 / Diabetes mellitus type 1 (disorder) / Diabetes mellitus: [juvenile] or [insulin dependent] / Juvenile diabetes / Insulin dependent diabetic / IDDM / Diabetes mellitus insulin-dependent / Insulin-dependent diabetes mellitus / Diabetes mellitus juvenile onset / Immune-mediated diabetes / Insulin dependent diabetes mellitus / Insulin dependent diabetes mel / IDDM - Insulin-dependent diabetes mellitus / Diabetes mellitus - juvenile / Ketosis-prone diabetes mellitus (disorder) / Ketosis-prone diabetes mellitus

Indication	Status	Phase
DBCOND0076728 (Type One Diabetes)	Completed	1

clinicaltrials.gov Identifier	Title	Purpose	Drugs
NCT01792323	Absorption of Insulin Following Subcutaneous Bolus Administration With Different Bolus Durations	Basic Science	Insulin lispro (DB00046)
NCT01811849	Pharmacokinetic and Injection Site Toleration of BIOD-238 and BIOD-250 Compared to Humalog® in Subjects With Type 1 Diabetes	Treatment	Insulin lispro (DB00046)
NCT05373199	A Trial Comparing the Pharmacodynamics and Pharmacokinetics of BC Combo THDB0207 and Lantus® and Humalog® in Subjects With Type 1 Diabetes	Treatment	Insulin glargine (DB00047) Insulin lispro (DB00046)
NCT04501107	A Trial to Compare BioChaperone Insulin Lispro Formulations With US Approved Humalog® and With EU Approved Humalog® in Patients With Type 1 Diabetes Mellitus	Treatment	Insulin lispro (DB00046)
NCT03903016	A Bioequivalence Study Comparing Two Different Strengths Formulations of Insulin Lispro in Patients With Type 1 Diabetes	Treatment	Insulin lispro (DB00046)
NCT02273258	A Study to Compare Pharmacokinetics and Pharmacodynamics of SAR342434 to Insulin Lispro in Subjects With Type 1 Diabetes	Treatment	Insulin lispro (DB00046)
NCT00652288	Evaluation of Pharmacokinetics and Pharmacodynamic Properties of Rapid-Acting Insulin Analogs	Treatment	Insulin aspart (DB01306) Insulin detemir (DB01307) Insulin glargine (DB00047) Insulin human (DB00030) Insulin lispro (DB00046)
NCT03367390	A Study of an Automated Insulin Delivery System in Participants With Type 1 Diabetes Mellitus (T1DM)	Device Feasibility	Insulin lispro (DB00046)
NCT03179332	A Trial to Evaluate the Pharmacokinetic and Pharmacodynamic Properties of BioChaperone® Insulin Lispro, Fiasp® and NovoRapid® Delivered by an Insulin Pump	Treatment	Insulin aspart (DB01306) Insulin lispro (DB00046)
NCT07090824	Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes	Basic Science	Insulin human (DB00030) Insulin lispro (DB00046) Linezolid (DB00601) Mannitol (DB00742)
NCT05262387	A Study of LY900014 (Lyumjev) Versus Insulin Lispro (Humalog) in Participants With Type 1 Diabetes	Basic Science	Insulin lispro (DB00046)
NCT03166124	A Study of LY900014 in Elderly and Younger Adult Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin lispro (DB00046)
NCT03449433	A Meal Test Study of LY900014 in Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin aspart (DB01306) Insulin lispro (DB00046)
NCT03407118	A Study of LY900014 in Japanese Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin lispro (DB00046)
NCT03056456	A Study of LY900014 Administered in Participants With Type 1 Diabetes Using an Insulin Pump	Basic Science	Insulin lispro (DB00046)
NCT02703324	A Study of LY900014 Formulation in Participants With Type 1 Diabetes Mellitus Using Insulin Pumps	Basic Science	Insulin lispro (DB00046)
NCT02344992	Blood Glucose Control With BioChaperone Insulin Lispro Compared to Insulin Lispro (Humalog®) After Ingestion of a Standardized Meal	Treatment	Insulin lispro (DB00046)
NCT02213146	A Double-blinded, Randomised, Three-period Crossover Euglycaemic Clamp Trial Investigating the Pharmacokinetics, Glucodynamics and Safety of BioChaperone Human Insulin, Human Insulin (Huminsulin® Normal) and Insulin Lispro (Humalog®) in Subjects With Type 1 Diabetes	Treatment	Insulin human (DB00030) Insulin lispro (DB00046)
NCT02029924	A Double-blinded, Randomised, Two -Period Crossover Euglycemic Clamp Trial Investigating the Pharmacokinetics, Glucodynamics and Safety of BioChaperone Insulin Lispro and Insulin Lispro (Humalog®) in Subjects With Type 1 Diabetes	Treatment	Insulin lispro (DB00046)
NCT01981031	A Trial to Assess the Efficacy and Safety of BioChaperone Combo and Humalog Mix 25 in Subjects With Type 1 Diabetes	Treatment	Insulin lispro (DB00046)
NCT01334151	Pharmacokinetic and Pharmacodynamic Properties of BIOD-105 and BIOD-107 Compared to Humalog® in Subjects With Type 1 Diabetes	Treatment	Insulin human (DB00030) Insulin lispro (DB00046)
NCT05067270	A Study of Infusion Site Pain After Infusion of Excipients in Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin lispro (DB00046) Magnesium chloride (DB09407) Sodium citrate (DB09154) Treprostinil (DB00374)
NCT02739906	A Trial to Investigate Post Prandial Blood Glucose Control With Fast-acting Human Insulin HinsBet® Compared to Insulin Lispro (Humalog®) and Regular Human Insulin (Huminsulin® Normal) After Ingestion of a Standardized Meal in Subjects With T1DM	Treatment	Insulin human (DB00030) Insulin lispro (DB00046)
NCT03512236	A Trial to Investigate Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BioChaperone® Pramlintide Insulin in Patients With Type 1 Diabetes Mellitus	Treatment	Insulin human (DB00030) Insulin lispro (DB00046) Pramlintide (DB01278)
NCT02562313	A Trial Investigating the Continuous Subcutaneous Insulin Infusion of a Liquid Formulation of BioChaperone Insulin Lispro in Comparison to Humalog®	Treatment	Insulin lispro (DB00046)
NCT02713841	Pharmacologic Response and Safety of Inhaled Insulin in Type 1 Diabetes		Insulin human (DB00030) Insulin lispro (DB00046)
NCT04161976	A Study of LY900027 Given by Insulin Pump to Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin lispro (DB00046)
NCT03916640	A Trial to Assess a Co-formulation of an Insulin Analog and Pramlintide in Subjects With Type 1 Diabetes Mellitus	Treatment	Insulin human (DB00030) Insulin lispro (DB00046) Pramlintide (DB01278)
NCT02703350	A Study of LY900014 in Participants With Type 1 Diabetes on Insulin Injection Therapy	Basic Science	Insulin lispro (DB00046)
NCT02152384	A Study to Compare and Measure the Effects of Insulin Peglispro (LY2605541) and Glargine on Meal Time Insulin Requirements	Basic Science	Insulin glargine (DB00047) Insulin lispro (DB00046) Insulin peglispro (DB11567)
NCT02514954	Postprandial Blood Glucose Control With BioChaperone® Combo and Insulin Lispro (Humalog®) Mix 25 in People With Type 1 Diabetes Mellitus	Treatment	Insulin lispro (DB00046)
NCT03465878	A Study of LY900014 in Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin lispro (DB00046)
NCT04276207	A Study of LY900014 Versus Insulin Lispro (Humalog) on High Blood Sugar in Participants With Type 1 Diabetes Who Use Insulin Pumps	Basic Science	Insulin lispro (DB00046)
NCT02470637	Single Dose Clamp Study to Evaluate Concentration-time Profile and Metabolic Activity of 3 Dose Levels of Afrezza and 3 Dose Levels of Insulin Lispro in Patients With Type 1 Diabetes Mellitus	Basic Science	Insulin human (DB00030) Insulin lispro (DB00046)
NCT03341299	A Comparative Study of LY900014 With Insulin Lispro (Humalog) in Participants With Type 1 Diabetes Mellitus	Basic Science	Insulin lispro (DB00046)
NCT02528396	To Investigate the Efficacy and Safety of Individualized Doses of BioChaperone Insulin Lispro in Comparison to Humalog® U-100 in Patients With Type 1 Diabetes Mellitus	Treatment	Insulin lispro (DB00046)
NCT01311076	TAK-329 Glucose Clamp Study		Insulin human (DB00030) Insulin lispro (DB00046)
NCT00810589	A Randomised, Single Centre, Double-Blind, Two-Period Crossover, Glucose Clamp Trial	Treatment	Insulin detemir (DB01307) Insulin human (DB00030) Insulin lispro (DB00046)
NCT03170544	Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)	Treatment	Insulin glargine (DB00047) Insulin human (DB00030) Insulin lispro (DB00046)
NCT02603510	Assessment of the Safety of SAR342434 and Humalog® When Administered as Continuous Subcutaneous Insulin Infusion	Treatment	Insulin lispro (DB00046)
NCT02500979	Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus	Treatment	Insulin human (DB00030) Insulin lispro (DB00046) Linezolid (DB00601) Pramlintide (DB01278)