Aldo-keto reductase family 1 member B15
Details
- Name
- Aldo-keto reductase family 1 member B15
- Synonyms
- 1.1.1.-
- 1.1.1.300
- 1.1.1.54
- Estradiol 17-beta-dehydrogenase AKR1B15
- Farnesol dehydrogenase
- Testosterone 17beta-dehydrogenase
- Gene Name
- AKR1B15
- UniProtKB Entry
- C9JRZ8Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052191|Aldo-keto reductase family 1 member B15 MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD FKEFSHLEDFPFDAEY
- Number of residues
- 316
- Molecular Weight
- 36536.795
- Theoretical pI
- Not Available
- GO Classification
- Functionsaldose reductase (NADPH) activity / all-trans-retinol dehydrogenase (NADP+) activity / estradiol 17-beta-dehydrogenase [NAD(P)+] activity
- General Function
- Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (PubMed:21276782, PubMed:26222439). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs (PubMed:25577493). Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal (PubMed:26222439). May play a physiological role in retinoid metabolism (PubMed:26222439)
- Specific Function
- aldose reductase (NADPH) activity
- Pfam Domain Function
- Aldo_ket_red (PF00248)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0052192|Aldo-keto reductase family 1 member B15 (AKR1B15) ATGGTCTTACAAATGGAACCCCAAGTGAACTCAACTAACAACTTCCACCAAGGACCCCTG GACCAACCCGTTGGCCCTTTGACTGGCCTAAAGAGTTCCCTTCTGAAGGACACTACAAGT GCAGGGCCCCTTCTTCGCCCCTATCCAGCATCTCTTCTCGGCAAAGTGAAAGAAGCGGTG AAGGTGGCCATTGATGCAGAATATCGCCACATTGACTGTGCCTATTTCTATGAGAATCAA CATGAGGTGGGAGAAGCCATCCAAGAGAAGATCCAAGAGAAGGCTGTGATGCGGGAGGAC CTGTTCATCGTCAGCAAGGTGTGGCCCACTTTCTTTGAGAGACCCCTTGTGAGGAAAGCC TTTGAGAAGACCCTCAAGGACCTGAAGCTGAGCTATCTGGACGTCTATCTTATTCACTGG CCACAGGGATTCAAGACTGGGGATGACTTTTTCCCCAAAGATGATAAAGGTAATATGATC AGTGGAAAAGGAACGTTCTTGGATGCCTGGGAGGCCATGGAGGAGCTGGTGGACGAGGGG CTGGTGAAAGCCCTTGGGGTCTCAAATTTCAACCACTTCCAGATCGAGAGGCTCTTGAAC AAACCTGGACTGAAATATAAACCAGTGACTAACCAGGTTGAGTGTCACCCATACCTCACG CAGGAGAAACTGATCCAGTACTGCCACTCCAAGGGCATCACCGTTACGGCCTACAGCCCC CTGGGCTCTCCGGATAGACCTTGGGCCAAACCTGAGGACCCTTCCCTGCTGGAGGATCCC AAGATTAAGGAGATTGCTGCAAAGCACAAAAAAACCACAGCCCAGGTTCTGATCCGTTTC CATATCCAGAGGAATGTGACAGTGATCCCCAAGTCTATGACACCAGCACACATTGTTGAG AACATTCAGGTCTTTGACTTTAAATTGAGTGATGAGGAGATGGCAACCATACTCAGCTTC AACAGAAACTGGAGGGCCTTTGACTTCAAGGAATTCTCTCATTTGGAGGACTTTCCCTTC GATGCAGAATATTGA
- Chromosome Location
- 7
- Locus
- 7q33
- External Identifiers
Resource Link UniProtKB ID C9JRZ8 UniProtKB Entry Name AK1BF_HUMAN GeneCard ID AKR1B15 HGNC ID HGNC:37281 KEGG ID hsa:441282 NCBI Gene ID 441282 - General References
- Salabei JK, Li XP, Petrash JM, Bhatnagar A, Barski OA: Functional expression of novel human and murine AKR1B genes. Chem Biol Interact. 2011 May 30;191(1-3):177-84. doi: 10.1016/j.cbi.2011.01.020. Epub 2011 Jan 27. [Article]
- Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [Article]
- Weber S, Salabei JK, Moller G, Kremmer E, Bhatnagar A, Adamski J, Barski OA: Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45. doi: 10.1074/jbc.M114.610121. Epub 2015 Jan 10. [Article]
- Gimenez-Dejoz J, Kolar MH, Ruiz FX, Crespo I, Cousido-Siah A, Podjarny A, Barski OA, Fanfrlik J, Pares X, Farres J, Porte S: Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase. PLoS One. 2015 Jul 29;10(7):e0134506. doi: 10.1371/journal.pone.0134506. eCollection 2015. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Aldo-keto reductase family 1 member B15 (Humans) protein primaryAldo-keto reductase family (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Lumateperone approved, investigational no enzyme substrate Details