The DNA sequence of human chromosome 7.

Article Details

Citation

Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK

The DNA sequence of human chromosome 7.

Nature. 2003 Jul 10;424(6945):157-64.

PubMed ID
12853948 [ View in PubMed
]
Abstract

Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first metacentric chromosome completed so far. The sequence has excellent concordance with previously established physical and genetic maps, and it exhibits an unusual amount of segmentally duplicated sequence (8.2%), with marked differences between the two arms. Our initial analyses have identified 1,150 protein-coding genes, 605 of which have been confirmed by complementary DNA sequences, and an additional 941 pseudogenes. Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Alpha-aminoadipic semialdehyde synthase, mitochondrialQ9UDR5Details
Potassium voltage-gated channel subfamily H member 2Q12809Details
3-hydroxyisobutyrate dehydrogenase, mitochondrialP31937Details
Thiamin pyrophosphokinase 1Q9H3S4Details
2-oxoglutarate dehydrogenase, mitochondrialQ02218Details
Asparagine synthetase [glutamine-hydrolyzing]P08243Details
Plasminogen activator inhibitor 1P05121Details
Nitric oxide synthase, endothelialP29474Details
Adenylate cyclase type 1Q08828Details
Calcium-binding mitochondrial carrier protein Aralar2Q9UJS0Details
Amiloride-sensitive amine oxidase [copper-containing]P19801Details
Peroxisomal carnitine O-octanoyltransferaseQ9UKG9Details
AcetylcholinesteraseP22303Details
Calcitonin receptorP30988Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Q16718Details
Argininosuccinate lyaseP04424Details
Growth hormone-releasing hormone receptorQ02643Details
Serine/threonine-protein kinase B-rafP15056Details
Dihydrolipoyl dehydrogenase, mitochondrialP09622Details
Biliverdin reductase AP53004Details
Inosine-5'-monophosphate dehydrogenase 1P20839Details
Malate dehydrogenase, mitochondrialP40926Details
Niemann-Pick C1-like protein 1Q9UHC9Details
Glutathione S-transferase kappa 1Q9Y2Q3Details
Metabotropic glutamate receptor 8O00222Details
Maltase-glucoamylase, intestinalO43451Details
Receptor activity-modifying protein 3O60896Details
Lanosterol 14-alpha demethylaseQ16850Details
Aquaporin-1P29972Details
Histone deacetylase 9Q9UKV0Details
Cyclin-dependent-like kinase 5Q00535Details
Hepatocyte growth factor receptorP08581Details
Serum paraoxonase/arylesterase 1P27169Details
Insulin-like growth factor-binding protein 3P17936Details
Beta-glucuronidaseP08236Details
Glycine--tRNA ligaseP41250Details
Cytochrome cP99999Details
Peptidyl-prolyl cis-trans isomerase AP62937Details
Multidrug resistance protein 1P08183Details
ElastinP15502Details
Ras-related C3 botulinum toxin substrate 1P63000Details
Hepatocyte growth factorP14210Details
Cystic fibrosis transmembrane conductance regulatorP13569Details
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformP48736Details
Trypsin-1P07477Details
Thromboxane-A synthaseP24557Details
Aromatic-L-amino-acid decarboxylaseP20711Details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3O60568Details
Cyclin-dependent kinase 6Q00534Details
Vitamin K epoxide reductase complex subunit 1-like protein 1Q8N0U8Details
Metabotropic glutamate receptor 3Q14832Details
Cytochrome P450 3A5P20815Details
NADPH--cytochrome P450 reductaseP16435Details
ATP-binding cassette sub-family B member 5Q2M3G0Details
Nicotinamide phosphoribosyltransferaseP43490Details
Mismatch repair endonuclease PMS2P54278Details
Zinc-alpha-2-glycoproteinP25311Details
Heat shock protein beta-1P04792Details
Transmembrane glycoprotein NMBQ14956Details
Pro-neuropeptide YP01303Details
Cytochrome P450 3A43Q9HB55Details
Serum paraoxonase/lactonase 3Q15166Details
Potassium voltage-gated channel subfamily D member 2Q9NZV8Details
3-oxo-5-beta-steroid 4-dehydrogenaseP51857Details
Phosphatidylcholine translocator ABCB4P21439Details
ATP-binding cassette sub-family B member 8, mitochondrialQ9NUT2Details
Aryl hydrocarbon receptorP35869Details
T-cell receptor beta-1 chain C regionP01850Details
Actin-related protein 2/3 complex subunit 1BO15143Details
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialQ16654Details
SRSF protein kinase 2P78362Details
Aldo-keto reductase family 1 member B10O60218Details
Homeobox protein engrailed-2P19622Details
Guanine nucleotide-binding protein G(i) subunit alpha-1P63096Details
Ras-related protein Ral-AP11233Details
GTP-binding protein RhebQ15382Details
LIM domain kinase 1P53667Details
Transferrin receptor protein 2Q9UP52Details
Neutrophil cytosol factor 1P14598Details
5'-AMP-activated protein kinase subunit gamma-2Q9UGJ0Details
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CQ14123Details
Actin, cytoplasmic 1P60709Details
Transient receptor potential cation channel subfamily V member 5Q9NQA5Details
SorcinP30626Details
Calcium-dependent secretion activator 2Q86UW7Details
Homeobox protein Hox-A10P31260Details
Taste receptor type 2 member 16Q9NYV7Details
ZyxinQ15942Details
Ephrin type-A receptor 1P21709Details
Ephrin type-B receptor 6O15197Details
Homeodomain-interacting protein kinase 2Q9H2X6Details
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformQ16816Details
Serine/threonine-protein kinase 17AQ9UEE5Details
Histone-lysine N-methyltransferase EZH2Q15910Details
Aldo-keto reductase family 1 member B15C9JRZ8Details
PendrinO43511Details
Serum paraoxonase/arylesterase 2Q15165Details
Diacylglycerol kinase betaQ9Y6T7Details
Tyrosine-protein phosphatase non-receptor type 12Q05209Details
V-type proton ATPase subunit e 2Q8NHE4Details
V-type proton ATPase 116 kDa subunit a isoform 4Q9HBG4Details
V-type proton ATPase subunit FQ16864Details
Hyaluronidase PH-20P38567Details
Hyaluronidase-4Q2M3T9Details
Receptor protein-tyrosine kinaseQ504U8Details