The DNA sequence of human chromosome 7.
Article Details
- CitationCopy to clipboard
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
The DNA sequence of human chromosome 7.
Nature. 2003 Jul 10;424(6945):157-64.
- PubMed ID
- 12853948 [ View in PubMed]
- Abstract
Human chromosome 7 has historically received prominent attention in the human genetics community, primarily related to the search for the cystic fibrosis gene and the frequent cytogenetic changes associated with various forms of cancer. Here we present more than 153 million base pairs representing 99.4% of the euchromatic sequence of chromosome 7, the first metacentric chromosome completed so far. The sequence has excellent concordance with previously established physical and genetic maps, and it exhibits an unusual amount of segmentally duplicated sequence (8.2%), with marked differences between the two arms. Our initial analyses have identified 1,150 protein-coding genes, 605 of which have been confirmed by complementary DNA sequences, and an additional 941 pseudogenes. Of genes confirmed by transcript sequences, some are polymorphic for mutations that disrupt the reading frame.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Alpha-aminoadipic semialdehyde synthase, mitochondrial Q9UDR5 Details Potassium voltage-gated channel subfamily H member 2 Q12809 Details 3-hydroxyisobutyrate dehydrogenase, mitochondrial P31937 Details Thiamin pyrophosphokinase 1 Q9H3S4 Details 2-oxoglutarate dehydrogenase, mitochondrial Q02218 Details Asparagine synthetase [glutamine-hydrolyzing] P08243 Details Plasminogen activator inhibitor 1 P05121 Details Nitric oxide synthase, endothelial P29474 Details Adenylate cyclase type 1 Q08828 Details Calcium-binding mitochondrial carrier protein Aralar2 Q9UJS0 Details Amiloride-sensitive amine oxidase [copper-containing] P19801 Details Peroxisomal carnitine O-octanoyltransferase Q9UKG9 Details Acetylcholinesterase P22303 Details Calcitonin receptor P30988 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Q16718 Details Argininosuccinate lyase P04424 Details Growth hormone-releasing hormone receptor Q02643 Details Serine/threonine-protein kinase B-raf P15056 Details Dihydrolipoyl dehydrogenase, mitochondrial P09622 Details Biliverdin reductase A P53004 Details Inosine-5'-monophosphate dehydrogenase 1 P20839 Details Malate dehydrogenase, mitochondrial P40926 Details Niemann-Pick C1-like protein 1 Q9UHC9 Details Glutathione S-transferase kappa 1 Q9Y2Q3 Details Metabotropic glutamate receptor 8 O00222 Details Maltase-glucoamylase, intestinal O43451 Details Receptor activity-modifying protein 3 O60896 Details Lanosterol 14-alpha demethylase Q16850 Details Aquaporin-1 P29972 Details Histone deacetylase 9 Q9UKV0 Details Cyclin-dependent-like kinase 5 Q00535 Details Hepatocyte growth factor receptor P08581 Details Serum paraoxonase/arylesterase 1 P27169 Details Insulin-like growth factor-binding protein 3 P17936 Details Beta-glucuronidase P08236 Details Glycine--tRNA ligase P41250 Details Cytochrome c P99999 Details Peptidyl-prolyl cis-trans isomerase A P62937 Details Multidrug resistance protein 1 P08183 Details Elastin P15502 Details Ras-related C3 botulinum toxin substrate 1 P63000 Details Hepatocyte growth factor P14210 Details Cystic fibrosis transmembrane conductance regulator P13569 Details Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 Details Trypsin-1 P07477 Details Thromboxane-A synthase P24557 Details Aromatic-L-amino-acid decarboxylase P20711 Details Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 O60568 Details Cyclin-dependent kinase 6 Q00534 Details Vitamin K epoxide reductase complex subunit 1-like protein 1 Q8N0U8 Details Metabotropic glutamate receptor 3 Q14832 Details Cytochrome P450 3A5 P20815 Details NADPH--cytochrome P450 reductase P16435 Details ATP-binding cassette sub-family B member 5 Q2M3G0 Details Nicotinamide phosphoribosyltransferase P43490 Details Mismatch repair endonuclease PMS2 P54278 Details Zinc-alpha-2-glycoprotein P25311 Details Heat shock protein beta-1 P04792 Details Transmembrane glycoprotein NMB Q14956 Details Pro-neuropeptide Y P01303 Details Cytochrome P450 3A43 Q9HB55 Details Serum paraoxonase/lactonase 3 Q15166 Details Potassium voltage-gated channel subfamily D member 2 Q9NZV8 Details 3-oxo-5-beta-steroid 4-dehydrogenase P51857 Details Phosphatidylcholine translocator ABCB4 P21439 Details ATP-binding cassette sub-family B member 8, mitochondrial Q9NUT2 Details Aryl hydrocarbon receptor P35869 Details T-cell receptor beta-1 chain C region P01850 Details Actin-related protein 2/3 complex subunit 1B O15143 Details [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Q16654 Details SRSF protein kinase 2 P78362 Details Aldo-keto reductase family 1 member B10 O60218 Details Homeobox protein engrailed-2 P19622 Details Guanine nucleotide-binding protein G(i) subunit alpha-1 P63096 Details Ras-related protein Ral-A P11233 Details GTP-binding protein Rheb Q15382 Details LIM domain kinase 1 P53667 Details Transferrin receptor protein 2 Q9UP52 Details Neutrophil cytosol factor 1 P14598 Details 5'-AMP-activated protein kinase subunit gamma-2 Q9UGJ0 Details Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C Q14123 Details Actin, cytoplasmic 1 P60709 Details Transient receptor potential cation channel subfamily V member 5 Q9NQA5 Details Sorcin P30626 Details Calcium-dependent secretion activator 2 Q86UW7 Details Homeobox protein Hox-A10 P31260 Details Taste receptor type 2 member 16 Q9NYV7 Details Zyxin Q15942 Details Ephrin type-A receptor 1 P21709 Details Ephrin type-B receptor 6 O15197 Details Homeodomain-interacting protein kinase 2 Q9H2X6 Details Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Q16816 Details Serine/threonine-protein kinase 17A Q9UEE5 Details Histone-lysine N-methyltransferase EZH2 Q15910 Details Aldo-keto reductase family 1 member B15 C9JRZ8 Details Pendrin O43511 Details Serum paraoxonase/arylesterase 2 Q15165 Details Diacylglycerol kinase beta Q9Y6T7 Details Tyrosine-protein phosphatase non-receptor type 12 Q05209 Details V-type proton ATPase subunit e 2 Q8NHE4 Details V-type proton ATPase 116 kDa subunit a isoform 4 Q9HBG4 Details V-type proton ATPase subunit F Q16864 Details Hyaluronidase PH-20 P38567 Details Hyaluronidase-4 Q2M3T9 Details Receptor protein-tyrosine kinase Q504U8 Details Protein Wnt-2 P09544 Details Inhibin beta A chain P08476 Details Mucin-3A Q02505 Details