Orexin receptor type 1
Details
- Name
- Orexin receptor type 1
- Synonyms
- Hypocretin receptor type 1
- Ox-1-R
- Gene Name
- HCRTR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019820|Orexin receptor type 1 MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV TTVLP
- Number of residues
- 425
- Molecular Weight
- 47535.33
- Theoretical pI
- Not Available
- GO Classification
- FunctionsG-protein coupled receptor activity / neuropeptide receptor activity / orexin receptor activity / peptide binding / peptide hormone bindingProcessescellular response to hormone stimulus / feeding behavior / neuropeptide signaling pathway / regulation of circadian sleep/wake cycle, sleep / response to peptide / synaptic transmissionComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Peptide hormone binding
- Specific Function
- Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 47-67 81-102 120-142 165-185 217-239 299-321 337-360
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019821|Orexin receptor type 1 (HCRTR1) ATGGAGCCCTCAGCCACCCCAGGGGCCCAGATGGGGGTCCCCCCTGGCAGCAGAGAGCCG TCCCCTGTGCCTCCAGACTATGAAGATGAGTTTCTCCGCTATCTGTGGCGCGATTATCTG TACCCAAAACAGTATGAGTGGGTCCTCATCGCAGCCTATGTGGCTGTGTTCGTCGTGGCC CTGGTGGGCAACACGCTGGTCTGCCTGGCCGTGTGGCGGAACCACCACATGAGGACAGTC ACCAACTACTTCATTGTCAACCTGTCCCTGGCTGACGTTCTGGTGACTGCTATCTGCCTG CCGGCCAGCCTGCTGGTGGACATCACTGAGTCCTGGCTGTTCGGCCATGCCCTCTGCAAG GTCATCCCCTATCTACAGGCTGTGTCCGTGTCAGTGGCAGTGCTAACTCTCAGCTTCATC GCCCTGGACCGCTGGTATGCCATCTGCCACCCACTATTGTTCAAGAGCACAGCCCGGCGG GCCCGTGGCTCCATCCTGGGCATCTGGGCTGTGTCGCTGGCCATCATGGTGCCCCAGGCT GCAGTCATGGAATGCAGCAGTGTGCTGCCTGAGCTAGCCAACCGCACACGGCTCTTCTCA GTCTGTGATGAACGCTGGGCAGATGACCTCTATCCCAAGATCTACCACAGTTGCTTCTTT ATTGTCACCTACCTGGCCCCACTGGGCCTCATGGCCATGGCCTATTTCCAGATATTCCGC AAGCTCTGGGGCCGCCAGATCCCCGGCACCACCTCAGCACTGGTGCGGAACTGGAAGCGC CCCTCAGACCAGCTGGGGGACCTGGAGCAGGGCCTGAGTGGAGAGCCCCAGCCCCGGGCC CGCGCCTTCCTGGCTGAAGTGAAGCAGATGCGTGCACGGAGGAAGACAGCCAAGATGCTG ATGGTGGTGCTGCTGGTCTTCGCCCTCTGCTACCTGCCCATCAGCGTCCTCAATGTCCTT AAGAGGGTGTTCGGGATGTTCCGCCAAGCCAGTGACCGCGAAGCTGTCTACGCCTGCTTC ACCTTCTCCCACTGGCTGGTGTACGCCAACAGCGCTGCCAACCCCATCATCTACAACTTC CTCAGTGGCAAATTCCGGGAGCAGTTTAAGGCTGCCTTCTCCTGCTGCCTGCCTGGCCTG GGTCCCTGCGGCTCTCTGAAGGCCCCTAGTCCCCGCTCCTCTGCCAGCCACAAGTCCTTG TCCTTGCAGAGCCGATGCTCCATCTCCAAAATCTCTGAGCATGTGGTGCTCACCAGCGTC ACCACAGTGCTGCCCTGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O43613 UniProtKB Entry Name OX1R_HUMAN HGNC ID HGNC:4848 - General References
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